Use of platelet aggregometry in selection of compatible platelet donors

The New England Journal of Medicine
K K WuJ A Koepke

Abstract

To determine if platelet aggregometry was useful in selecting compatible platelet donors, six patients who had become refractory to random platelets were studied. Serum from the patient was added to citrated platelet-rich plasma from the prospective donor in a standard aggregometry system. Serial aggregometry studies revealed no platelet aggregation unless the refractory state had been reached. At that time positive aggregation occurred only between the poorly matched pairs. A correlation between platelet aggregation and HL-A histocompatibility was noted. Family members with negative aggregation were selected as donors, and their platelets were able to provide consistently satisfactory increments in the platelet count of the recipient who was refractory to random donors. In contrast, platelets from family members who exhibited positive aggregation failed to do so. These findings suggest that platelet aggregometry can be used to select compatible platelet donors.

References

Apr 1, 1974·Transplantation·J S ThompsonJ R Corry
Dec 1, 1972·The Journal of Clinical Investigation·D Deykin, L J Hellerstein
Apr 12, 1973·The New England Journal of Medicine·R A YankeeE S Henderson
Jan 1, 1974·Annals of Internal Medicine·H P LohrmannR G Graw
Nov 1, 1971·Transfusion·J L TullisK Murthy
Mar 1, 1969·Transplantation·D B AmosA Tiilikainen
May 3, 1962·The New England Journal of Medicine·L A GAYDOSN MANTEL
May 1, 1964·The Journal of Clinical Investigation·R H ASTER, J H JANDL

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Citations

Aug 1, 1977·Vox Sanguinis·D HeinrichC Mueller-Eckhardt
Aug 1, 1976·The Journal of Clinical Investigation·K K WuR Flink
Nov 1, 1980·The American Journal of the Medical Sciences·P A Daly
Apr 1, 1981·Vox Sanguinis·L O Cook, W V Miller
Jan 1, 1984·British Journal of Haematology·J FreedmanM B Garvey
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·C R Valeri
Jan 1, 1978·American Journal of Hematology·R H Aster
Oct 1, 1988·American Journal of Hematology·K A Schwartz
Jan 1, 1977·American Journal of Hematology·R W Colman, G J Busch
Mar 1, 1990·American Journal of Hematology·K A SchwartzJ M Davis

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