Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs

Talanta
Román-Hidalgo CristinaBello-López Miguel Ángel

Abstract

The use of polymer inclusion membranes (PIMs) as support of 1-octanol liquid membrane in electromembrane extraction (EME) procedure is proposed. Synthesis of PIMs were optimized to a composition of 29% (w/w) of cellulose triacetate as base polymer and 71% (w/w) of Aliquat®336 as cationic carrier. Flat PIMs of 25µm thickness and 6mm diameter were used. EME protocol was implemented for the simultaneous extraction of four non-steroidal anti-inflammatory drugs (NSAIDs) (salicylic acid, ketoprofen, naproxen and ibuprofen) and four highly polar acidic drugs (anthranilic acid, nicotinic acid, amoxicillin and hippuric acid). Posterior HPLC separation of the extracted analytes was developed with diode array detection. Recoveries in the 81-34% range were obtained. EME procedure was applied to human urine samples.

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Nov 14, 2016·Talanta·Cristina Román-HidalgoMiguel Ángel Bello-López

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Citations

Mar 28, 2019·Electrophoresis·Cristina Roman-HidalgoStig Pedersen-Bjergaard
Dec 20, 2018·Analytical and Bioanalytical Chemistry·Stig Pedersen-Bjergaard
Jul 23, 2020·Analytical and Bioanalytical Chemistry·Noemí Aranda-MerinoRut Fernández-Torres
Jun 4, 2020·Journal of Separation Science·Magnus Saed RestanStig Pedersen-Bjergaard
Apr 7, 2019·Talanta·Cristina Román-HidalgoMiguel Ángel Bello-López
Apr 23, 2021·Analytical and Bioanalytical Chemistry·Elia SantigosaMaría Ramos-Payán

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