Use of porous membranes in tissue barrier and co-culture models

Lab on a Chip
Henry H ChungT R Gaborski

Abstract

Porous membranes enable the partitioning of cellular microenvironments in vitro, while still allowing physical and biochemical crosstalk between cells, a feature that is often necessary for recapitulating physiological functions. This article provides an overview of the different membranes used in tissue barrier and cellular co-culture models with a focus on experimental design and control of these systems. Specifically, we discuss how the structural, mechanical, chemical, and even the optical and transport properties of different membranes bestow specific advantages and disadvantages through the context of physiological relevance. This review also explores how membrane pore properties affect perfusion and solute permeability by developing an analytical framework to guide the design and use of tissue barrier or co-culture models. Ultimately, this review offers insight into the important aspects one must consider when using porous membranes in tissue barrier and lab-on-a-chip applications.

References

Mar 1, 1972·Journal of Biomechanics·A Chamay, P Tschantz
Nov 24, 1999·The Journal of Physiology·C N Maganaris, J P Paul
May 17, 2000·Journal of Biomedical Materials Research·J DeutschT A Desai
Aug 3, 2002·Nature Reviews. Immunology·Clotilde ThérySebastian Amigorena
Jan 7, 2003·Biotechnology and Bioengineering·Sindhu M GopalanAndrew D McCulloch
Dec 3, 2003·Science·Bruce J HindsLeonidas G Bachas
Dec 18, 2004·Biomaterials·Robert B VernonThomas N Wight
Apr 19, 2005·Journal of Biomedical Materials Research. Part a·Parul Natvar PatelCharles W Patrick
Aug 3, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Yong Mao, Jean E Schwarzbauer
Dec 24, 2005·Physiological Reviews·Dolly Mehta, Asrar B Malik
Jan 21, 2006·American Journal of Physical Anthropology·Christopher RuffErik Trinkaus
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Feb 16, 2007·Nature·Christopher C StriemerPhilippe M Fauchet
May 23, 2007·Biomedical Microdevices·Abel L ThangawngMatthew R Glucksberg
Jun 1, 2007·Lab on a Chip·Zhanhui WangTodd Thorsen
Sep 8, 2007·Science·Adam W FeinbergKevin Kit Parker
Nov 16, 2007·Biomaterials·Hannes-Christian MoellerAli Khademhosseini
Jul 25, 2008·Lab on a Chip·Amir ShamlooSarah C Heilshorn
Aug 9, 2008·Biomedical Microdevices·Taesung KimMichel M Maharbiz
Mar 30, 2010·Trends in Biotechnology·Fabian ZanellaWolfgang Link
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Sep 8, 2010·The New England Journal of Medicine·Warren L Lee, Arthur S Slutsky
May 27, 2011·Lab on a Chip·Seila SelimovićAli Khademhosseini
Aug 2, 2011·Lab on a Chip·Jules J VanDersarlNicholas A Melosh
Dec 14, 2011·Advances in Colloid and Interface Science·Abhijit BiswasFranz Faupel
Mar 22, 2012·Nanotechnology·M N KavalenkaP M Fauchet
Apr 10, 2012·Annals of Biomedical Engineering·Jack D WangMohamed ElSayed
Mar 1, 2011·Materials Today·Riaz AkhtarBrian Derby
Oct 31, 2012·Lab on a Chip·Anil Kumar H AchyutaShivshankar S Sundaram
Nov 9, 2012·Science Translational Medicine·Donna M Dambach, Hirdesh Uppal

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Citations

Oct 9, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·Guillaume PerryRachel Lennon
Sep 26, 2020·Scientific Reports·Anna-Elisabeth KreuderLutz Kloke
Mar 17, 2020·Cellular and Molecular Bioengineering·Tejas S KhireJames L McGrath
Aug 1, 2020·Micromachines·Alexander H McMillanSasha Cai Lesher-Pérez
Aug 7, 2020·Lab on a Chip·M ZakharovaL I Segerink
Nov 12, 2020·American Journal of Physiology. Cell Physiology·Savannah R MosesJonathan W Song
Jan 30, 2021·Advanced Healthcare Materials·Meilin SunWenming Liu
Jan 29, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chengyao WangAbhinav Bhushan
Dec 12, 2020·Frontiers in Bioengineering and Biotechnology·Matthew IshahakAshutosh Agarwal
Feb 6, 2021·Trends in Biotechnology·Nathalie Picollet-D'hahanSéverine Le Gac
Mar 7, 2021·Nature Protocols·Linda GijzenHans Clevers
Mar 13, 2021·Advanced Materials Technologies·Shayan GholizadehThomas R Gaborski
Mar 25, 2021·Biosensors & Bioelectronics·Denise MarreroRosa Villa
Apr 4, 2021·Micromachines·Boris BuchroithnerJost Ludwig
May 18, 2021·Advanced Functional Materials·James J Tronolone, Abhishek Jain

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Methods Mentioned

BETA
confocal microscopy
irradiating
chip
fluorescence imaging
light scattering

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