Use of positron emission tomography for the assessment of skeletal muscle glucose metabolism

Nutrition
Oliver SelbergWolfgang Burchert

Abstract

Positron emission tomography (PET) is a unique tool for studying regional skeletal muscle glucose metabolism and blood flow in vivo. The application of PET in the assessment of skeletal muscle glucose metabolism depends on recent improvements in instrumentation, data analysis, and production of (18)F-fluorodeoxyglucose (FDG) and (15)O water. The data presented support the validity of the (15)O water model to measure blood flow and the FDG model for the determination of glucose uptake and glucose kinetic constants (influx, efflux, and phosphorylation) in skeletal muscle. However, quantification of absolute glucose transport and backflux rates should be applied with caution because those calculations are based on unproven assumptions such as validity of the lumped constant for these individual processes and constancy of the free and accessible intracellular glucose pool. It is evident that quantification of glucose fluxes using the triple tracer technology generates conflicting data that violate assumptions inherent in triple tracer or PET modeling. Further FDG-PET studies will have to solve those problems to provide more insight into the regulatory processes of glucose transport and phosphorylation of different insulin-resistant...Continue Reading

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Citations

Jan 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Dorthe SkovgaardAndreas Kjaer
Jul 16, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Davod Mohebbi-Kalhori
Mar 22, 2006·Clinical Nuclear Medicine·Yon Kwon IhnSoo Kyo Chung
May 9, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ursula G KyleClaude Pichard
Sep 25, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Uwe J F TietgeKlaus H W Böker
May 2, 2014·American Journal of Respiratory and Critical Care Medicine·Andrew M KimRichard J Schwab
Jan 11, 2020·Molecular Metabolism·Matteo BaucknehtCecilia Marini

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