Use of Positron Emission Tomography to Detect Recurrence and Associations With Survival in Patients With Lung and Esophageal Cancers

Journal of the National Cancer Institute
Mark A HealySandra L Wong

Abstract

Positron emission tomography (PET) scans are often used in cancer patients for staging, restaging, and monitoring for treatment response. These scans are also often used to detect recurrence in asymptomatic patients, despite a lack of evidence demonstrating improved survival. We sought to evaluate utilization of PET for this purpose and relationships with survival for patients with lung and esophageal cancers. Using national Surveillance, Epidemiology, and End Results (SEER) and Medicare-linked data, we identified incident patient cases from 2005 to 2009, with follow-up through 2011. We identified cohorts with primary lung (n = 97 152) and esophageal (n = 4446) cancers. Patient and tumor characteristics were used to calculate risk-adjusted two-year overall survival. Using Medicare claims, we examined PET utilization in person-years (to account for variable time in cohorts), excluding scans for staging and for follow-up of CT findings. We then stratified hospitals by quintiles of PET utilization for adjusted two-year survival analysis. All statistical tests were two-sided. There was statistically significant variation in utilization of PET. Lowest vs highest utilizing hospitals performed .05 (SD = 0.04) vs 0.70 (SD = 0.44) scans...Continue Reading

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Citations

Nov 19, 2019·The Breast Journal·Benjamin L FrancR Adams Dudley
Jun 4, 2016·The Oncologist·Keith D EatonRenato G Martins
Sep 7, 2017·Current Opinion in Gastroenterology·David H Ilson
Mar 7, 2020·Journal of the National Cancer Institute·Rustain L MorganCathy J Bradley
Jul 14, 2016·Journal of Oncology Practice·Rafael Santana-Davila, Renato Martins

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