Use of positron emission tomography to measure the effects of nalmefene on D1 and D2 dopamine receptors in rat brain

Brain Research
E M UnterwaldM J Kreek

Abstract

Positron emission tomography (PET) has been used in humans and in non-human primates to image and measure radioligand binding to neuroreceptors. The present study evaluated the feasibility of performing high-resolution PET experiments in a rodent model to measure receptor kinetics. The effects of acute and chronic administration of the opioid antagonist, nalmefene, on the binding activity of [11C]SCH23390 and [11C]N-methylspiperone at D1 and D2 dopamine receptors, respectively, was investigated in the rat. The interaction between central opioid and dopaminergic systems has been the focus of much attention due to their interactive role in mediating reinforcement and locomotor activity. In the present study, adult male Sprague-Dawley rats received either a single injection of 10 (mg/kg of nalmefene or control vehicle solution 1 h prior to the PET scan or were chronically administered 10 mg/kg/day of nalmefene or vehicle for 7 days by an osmotic minipump. Following acute administration of nalmefene, the binding potential of [11C]SCH23390 in the striatum was significantly increased. No changes in [11C]N-methylspiperone binding were found. Following chronic nalmefene administration, no significant change in either [11C]SCH23390 bind...Continue Reading

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Citations

Aug 26, 1998·Drug and Alcohol Dependence·M J Kreek, G F Koob
Oct 12, 2001·Current Opinion in Neurobiology·R E Jacobs, S R Cherry
Apr 25, 2000·Nuclear Medicine and Biology·N HayakawaM Senda
Jul 1, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gavin BartMary Jeanne Kreek
Apr 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pietro CottoneEric P Zorrilla
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·M J Kreek
Nov 20, 2013·The International Journal of Neuropsychopharmacology·Michael Soyka
Jul 13, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco LeriMary Jeanne Kreek
Mar 12, 2008·Reviews in the Neurosciences·Susanne NikolausHans-Wilhelm Müller
Jun 19, 2004·Reviews in the Neurosciences·Susanne NikolausRolf Larisch

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