Use of potentially inappropriate medications among ambulatory home-dwelling elderly patients with dementia: A review of the literature

Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC
Tejal PatelLinda Lee

Abstract

Older adults with dementia are at high risk for drug-related adverse outcomes. While much is known about potentially inappropriate medication use in older adults, its prevalence and characteristics among those with dementia are not as well elucidated. We conducted a literature review to examine the prevalence of potentially inappropriate medication use among home-dwelling older adults with dementia. Our secondary aim was to determine the most frequently implicated medications and factors associated with potentially inappropriate medication use. MEDLINE, EMBASE, CINAHL, and International Pharmaceutical Abstracts were searched between 1946 and 2014 for articles that referenced potentially inappropriate medication use and types of dementia. One reviewer screened all titles and abstracts from the initial search and full-text articles after the initial screen for eligibility, then 2 reviewers independently abstracted data from included studies. Searches yielded 81 articles, of which 7 met inclusion criteria. Prevalence of potentially inappropriate medication use varied from 15% to 46.8%. No single drug or drug class was reported consistently across all studies as the most frequent potentially inappropriate medication, but anticholin...Continue Reading

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Citations

Jul 12, 2018·Expert Opinion on Drug Safety·Tesfahun C EshetieLisa M Kalisch Ellett
Jun 29, 2018·International Clinical Psychopharmacology·Philipp HessmannBernhard Kis
Jun 14, 2019·Aging Clinical and Experimental Research·Pinar KucukdagliMehmet Akif Karan

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