PMID: 9168213May 1, 1997Paper

Use of preincisional ketorolac in hernia patients: intravenous versus surgical site

Regional Anesthesia
N R ConnellyD Page

Abstract

This study was designed to determine whether administration of ketorolac directly in the surgical site results in enhanced analgesia. A randomized double-blind study was undertaken at a university-affiliated tertiary care hospital. Thirty outpatients undergoing unilateral inguinal hernia repair by one of two surgeons under local anesthesia with sedation were evaluated. Patients were invited to participate in this investigation at the time of the preoperative surgical visit. Patients who had a contraindication to the use of ketorolac or who refused repair under local anesthesia with sedation were excluded. Patients received ketorolac 60 mg either via the parenteral route or directly in the surgical site (mixed with the local anesthetic). The outcome measures included visual analog pain scores, measured at two different times in the hospital, pain scores at rest and with movement 24 hours after surgery, time to first analgesic, and total analgesic requirement. The study revealed lower 24 hour movement-associated pain scores (P < .02), increased time to first analgesic (P < .03), and decreased oral analgesic consumption (P < .0002) in the surgical site group. Ketorolac provides enhanced patient comfort when it is administered in t...Continue Reading

Citations

Jul 21, 2000·Acta Anaesthesiologica Scandinavica·J RømsingJ B Dahl
Jan 15, 2005·World Journal of Surgery·Emmanouil PikoulisPanayiotis Tsatsoulis
Mar 3, 2005·The Journal of Bone and Joint Surgery. American Volume·Scott S Reuben, Evan F Ekman
Jun 29, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kenneth J KardashMichael J Tessler
Jul 4, 2009·Regional Anesthesia and Pain Medicine·Joseph M Neal
Jul 17, 1998·Anesthesiology·N R Connelly, S S Reuben
Jun 20, 2000·Diseases of the Colon and Rectum·R J PlaceC L Simmang
Nov 20, 2002·Expert Opinion on Pharmacotherapy·Allan GottschalkE Andrew Ochroch
Oct 3, 2006·Current Opinion in Anaesthesiology·P Tarkkila, P H Rosenberg
Nov 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J RømsingD stergaard
Oct 3, 2006·Current Opinion in Anaesthesiology·J C Stewart, M A Kostash

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