Use of Raman spectroscopy as a tool for in situ monitoring of microwave-promoted reactions

Nature Protocols
Nicholas E Leadbeater, Jason R Schmink

Abstract

The progress of microwave-promoted reactions can be monitored by interfacing a Raman spectrometer with a scientific microwave unit. The apparatus is assembled from commercially available components. It is used in this protocol to follow the base-catalyzed reaction of salicylaldehyde with ethylacetoacetate to yield 3-acetylcoumarin. It is possible to watch the reaction spectroscopically in real time, determine when it reaches completion and thus use it as a tool for rapid reaction optimization.

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Citations

Jan 11, 2014·Experimental & Molecular Medicine·Dong-Im ChoYoungkeun Ahn
Aug 6, 2014·Nature Communications·Aaron I Velez-RamirezFrank F Millenaar
Aug 2, 2014·European Journal of Medicinal Chemistry·Ajay KumarDhirender Kaushik
Aug 27, 2009·Organic & Biomolecular Chemistry·Jason R Schmink, Nicholas E Leadbeater
Jul 11, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sylvain ChristiaensJean Jacques Vanden Eynde
Apr 27, 2017·Journal of the American Chemical Society·Dongchang ChenMeilin Liu
Jul 2, 2016·Journal of Liposome Research·Héctor Vázquez-BecerraLuis Alberto Medina
Oct 3, 2008·Chemistry : a European Journal·Jason R SchminkNicholas E Leadbeater
Jun 27, 2008·AAOHN Journal : Official Journal of the American Association of Occupational Health Nurses·Leonard JasonSusan Torres-Harding
Sep 18, 2010·Nanoscale·Idalia Bilecka, Markus Niederberger
Aug 19, 2010·Chemical Communications : Chem Comm·Nicholas E Leadbeater
Jun 13, 2013·Nature Reviews. Neuroscience·David J NuttDavid E Nichols
Jul 22, 2017·Scientific Reports·Adil SalhiVladimir B Bajic
Sep 27, 2018·Scientific Reports·Aymeric MonteillierMuriel Cuendet
Jun 29, 2013·Transgenic Research·Amanda Alves de Paiva RollaAlexandre Lima Nepomuceno
Aug 24, 2019·Advances in Wound Care·Jacqueline C SilvaDulcineia S P Abdalla
Nov 5, 2020·Chemical Communications : Chem Comm·William J TippingDuncan Graham
Oct 3, 2021·Nature Communications·Hector CorderoEmmanuel Zorn

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