Use of Recombinant Bone Morphogenetic Protein Is Associated With Reduced Risk of Reoperation After Spine Fusion for Adult Spinal Deformity

Spine
Justin C PaulThomas J Errico

Abstract

Retrospective review. This study follows the inpatient-stay administrative data that were collected for a cohort of thousands of patients who had spine fusion surgery in the state of New York. We sought to examine adult spinal deformity (ASD) for reoperation events with and without the use of bone morphogenetic protein-2 (BMP). Randomized controlled trials have suggested that BMP may increase the likelihood of solid arthrodesis in spinal surgery. This would imply fewer reoperations for pseudarthrosis, but small cohort sizes are inadequate to monitor these events. The 2008-2011 New York State Inpatient Database was queried using International Classification of Diseases, Ninth Revision, Clinical Modification codes. Patients age 21 years and older with a diagnosis of scoliosis and an index fusion of greater than 2 spinal motion segments were included. Patient identifiers and linkage variables were used to identify revisits. The relative risk of reoperation was calculated. The use of BMP at the initial inpatient stay was used to define the 2 cohorts for relative risk assessment. A total of 3751 patients of ASD were identified in 2008. The use of BMP at the initial visit was performed at a rate of 37.6% for ASD. For posterior fusion...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Oct 24, 2002·Journal of Spinal Disorders & Techniques·J Kenneth BurkusThomas A Zdeblick
Jun 3, 2005·The Journal of Bone and Joint Surgery. American Volume·J Kenneth BurkusMichael C Longley
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Sep 6, 2013·The Journal of Bone and Joint Surgery. American Volume·Eugene J CarrageeBranko Kopjar
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Aug 22, 2014·The Journal of Bone and Joint Surgery. American Volume·Patrick J CahillAmer F Samdani

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Citations

May 7, 2016·Journal of Neurosurgery. Spine·Varun PuvanesarajahHamid Hassanzadeh
Dec 16, 2016·Clinical Spine Surgery : a Spine Publication·Varun PuvanesarajahHamid Hassanzadeh
Sep 14, 2017·Clinical Spine Surgery : a Spine Publication·Sohrab S VirkSafdar N Khan
May 10, 2017·Neurosurgery·Corinna C ZygourakisChristopher P Ames
May 6, 2020·JBJS Essential Surgical Techniques·Munish C GuptaKeith H Bridwell
May 6, 2021·The Journal of Bone and Joint Surgery. American Volume·Howard J SeehermanJohn M Wozney

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Software Mentioned

SPSS
Statistical Package for Social Sciences

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