PMID: 7547078Jan 1, 1994Paper

Use of recombinant interferon-alpha in human immunodeficiency virus (HIV)-infected individuals

Biotherapy
J RiveroP López Saura

Abstract

Interferon alpha (IFN-alpha) has anti-retroviral activity and is a possible HIV infection-limiting factor. The aim of this work is to prevent or delay disease progression in asymptomatic Human Immunodeficiency Virus (HIV) carriers. Recombinant IFN alpha-2b (3 x 10(6) IU 3 times weekly) was compared to no treatment (control) in a randomized trial. Endpoints were: (i) appearance of any CDC group IV symptoms and (ii) disease progression (which excluded shifts to group IVC2 or reversible IVA, or IVB). The trial lasted from October 1987 to February 1992. The trial was performed at the "Santiago de las Vegas" sanatorium, a specialized institution for the care of HIV-infected and AIDS patients. Subjects were anti-HIV-1 seropositive, Western blot-confirmed, asymptomatic (CDC group II), or with generalized lymphadenopathies (CDC group III). The groups had 79 (control) and 71 (IFN) patients. Long-term IFN-alpha treatments significantly reduced the proportion of patients who shifted to any group IV (control: 46/79; IFN: 14/71; p < 0.001) or developed AIDS (control: 27/79; IFN: 12/71; p < 0.05). IFN also delayed progression to AIDS (95% confidence interval for 0.5 probability of progression) from 67-83 to 116-180 months after infection. Th...Continue Reading

References

Apr 16, 1992·The New England Journal of Medicine·N M GrahamJ P Phair
Feb 1, 1992·AIDS Research and Human Retroviruses·M L FrancisH E Gendelman
Jan 1, 1991·Antimicrobial Agents and Chemotherapy·M S SmithJ S Pagano
Apr 1, 1991·AIDS Research and Human Retroviruses·M von SydowO Strannegård
Aug 1, 1990·AIDS Research and Human Retroviruses·H E GendelmanM S Meltzer
Nov 1, 1990·The Journal of Experimental Medicine·H E GendelmanC Dieffenbach
Dec 14, 1989·The New England Journal of Medicine·D D HoM Alam
Jan 1, 1987·AIDS Research and Human Retroviruses·K L HartshornM S Hirsch
Jan 1, 1984·Annals of the New York Academy of Sciences·O T PrebleJ A Sonnabend
Oct 1, 1982·The Journal of Infectious Diseases·E DeStefanoJ Vilcek
Oct 16, 1993·Lancet·N Scheper-Hughes

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Citations

Sep 25, 2010·The Journal of Infectious Diseases·J Judy Chang, Marcus Altfeld
Nov 13, 2002·Journal of Hematotherapy & Stem Cell Research·Pierre CordelierDavid S Strayer
Mar 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ferdinando DianzaniMaria R Capobianchi
Oct 30, 2012·The Journal of Infectious Diseases·Lucy A McNamara, Kathleen L Collins
Dec 24, 2010·Journal of Virology·Jennifer LuChen Liang
Nov 23, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jean-Philippe Herbeuval, Gene M Shearer
Jun 11, 2016·Expert Opinion on Biological Therapy·Antonio Rivero-JuárezAntonio Rivero
Dec 15, 2018·Journal of Leukocyte Biology·Helen E Cumming, Nollaig M Bourke

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