Use of recombinant proteins in the diagnosis of autoimmune connective tissue diseases

International Archives of Allergy and Immunology
C GalperinM E Gershwin

Abstract

The use of recombinant proteins has been an invaluable tool for the study of the structure and function of cell components, and the analysis of autoimmune-mediated responses. Furthermore, it has also been instrumental in facilitating the development of reliable assays for the detection of a number of autoantibodies. This article discusses basic aspects of recombinant DNA technology, as well as its applications and limitations in the diagnosis of autoimmune connective tissue diseases such as systemic lupus erythematosus, Sjogren's syndrome, systemic scleroderma, mixed connective tissue disease, autoimmune inflammatory myopathies and primary vasculitides.

Citations

Feb 1, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A M DvorakR P Schleimer
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Evie MelanitouGeorge S Eisenbarth
Jul 24, 2002·Progress in Histochemistry and Cytochemistry·Ann M Dvorak, Ellen S Morgan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Current Rheumatology Reports
Elisabeth Binder, Monika Edelbauer
International Journal of Rheumatic Diseases
Preeta K Chugh, Bhupinder S Kalra
© 2021 Meta ULC. All rights reserved