Use of rheumatoid arthritis impact of disease (RAID) in routine care; identification of DAS28 remission and unmet patient-reported outcomes

Rheumatology Advances in Practice
Jatin MistryPatrick Kiely

Abstract

The aim was to assess how the patient-reported outcome RA impact of disease (RAID) relates to DAS28 categories in routine care, its utility in identifying patients in DAS28 remission (RDAS) or low disease activity (LDAS) and the burden of unmet patient-reported needs in those achieving RDAS/LDAS. DAS28 and RAID scores were collected from patients with established RA attending for routine review. The relationship between RAID and DAS28 was assessed with univariate pairwise correlation and mixed-effects linear regression analyses. RAID <2 was defined as a patient-acceptable state. One hundred and ninety-eight patients were assessed, with 220 observations, using DAS28-CRP categories: 47.5% RDAS, 14.1% LDAS, 31.8% moderate DAS (MDAS) and 6.6% high DAS (HDAS). Both patient visual analog scale score and tender joint count exhibited a high statistical association with RAID using linear regression (P < 0.0001). The mean RAID score per DAS28-CRP category was RDAS 1.84, LDAS 4.78, MDAS 5.60 and HDAS 7.68, with a statistically significant increase in RAID per unit increase in DAS-CRP or DAS28-ESR on linear regression (P  < 0.001). Of 66 patients with RAID <2, 64 (97%) were in RDAS and 65 (98.5%) in RDAS/LDAS. Of 134 patients in RDAS/LDAS,...Continue Reading

References

Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee
Oct 2, 2013·Seminars in Arthritis and Rheumatism·Maurizio CutoloPiet L C M van Riel
Oct 29, 2015·RMD Open·Hanna W van SteenbergenAnnette H M van der Helm-van Mil
Nov 8, 2015·Arthritis Care & Research·Jasvinder A SinghTimothy McAlindon
Oct 5, 2017·Therapeutic Advances in Musculoskeletal Disease·Sofia Ajeganova, Tom Huizinga
Feb 28, 2019·Annals of the Rheumatic Diseases·Pomme B M PoppelaarsMaarten Boers

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Citations

Jun 7, 2020·Nature Reviews. Rheumatology·Peter C Taylor
Aug 3, 2020·Arthritis & Rheumatology·Casper G Schoemaker, Maarten P T de Wit
Jan 7, 2021·Current Rheumatology Reports·Gillian E FitzgeraldNigil Haroon
Mar 1, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Juan LiJing Wang

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Methods Mentioned

BETA
ESR
RAID

Software Mentioned

EULAR

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