PMID: 9186578May 23, 1997Paper

Use of Salmonella typhimurium TA 98, YG 1024 and YG 1021 and deconjugating enzymes for evaluating the mutagenicity from smokers' urine

Mutation Research
C Kuenemann-MigeotB Festy

Abstract

Four smokers were chosen for their different smoking habits, and their declared cigarette consumption confirmed by urinary measurement of nicotine and its metabolites. The promutagenicity of their urine was evaluated by the Ames test, modified according to Kado et al. (Mutation Res., 31 (1983)25-32) after extraction on XAD2 Amberlite resin. The different Salmonella typhimurium strains TA 98, YG 1021 and YG 1024 were compared to determine the presence of amino aromatic compounds in the urine of smokers of blond and black tobacco. The strain YG 1024 shows higher mutagenicity than TA 98 for extracts from the smoker's urine and more particularly from black tobacco smokers. In addition, the pretreatment of urine by external enzymatic systems (beta-glucuronidase or arylsulfatase) reveals the presence in the urine of glucurono- and sulfoconjugated forms of promutagens, including amino aromatic compounds.

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E Yamasaki, B N Ames
Jul 15, 1992·The American Journal of Medicine·D Carbone
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M S BryantS R Tannenbaum
Jul 1, 1981·Mutation Research·H TokiwaY Ohnishi
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Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H BartschP Vineis
Jan 1, 1931·Annals of Surgery·F L Hoffman

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Citations

Jul 1, 1999·Molecular Aspects of Medicine·A R Collins
Sep 4, 2012·Regulatory Toxicology and Pharmacology : RTP·Matthias K SchorpRuth Dempsey

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