Use of scanning electron microscopy in the evaluation of craniosynostosis

The Journal of Craniofacial Surgery
W Ozaki, S R Buchman

Abstract

The cause of craniosynostosis continues to elude researchers. Although several studies have looked at the ultrastructure of normal suture closure, no previous studies have examined the microarchitecture of the synostotic suture. Our goal was to assess the scanning electron microscope (SEM) as a viable and useful tool in examining craniosynostosis. Our hypothesis is that the SEM is a powerful analytical tool that can evaluate nonsynostotic, partial synostotic, and complete synostotic cranial sutures. We analyzed the cranial suture of 3 human infants with nonsyndromic sagittal craniosynostosis. The specimens were separated into three groups, which included regions of partial and complete synostosis and a region of open suture. Histological examination provided cellular and tissue data about craniosynostosis, whereas the SEM provided detailed information regarding the trabecular microarchitecture of the synostosed suture. The SEM produced quality images of complete and partially synostotic sutures and open sutures. At low magnification, the SEM characterized the general bony microarchitecture of cranial sutures in a manner different from, but complementary to, standard histological sections. At higher magnification, the SEM allowe...Continue Reading

Citations

Jun 23, 2009·Drug and Chemical Toxicology·Sohail EjazChae Woong Lim
Jul 1, 2015·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·W NowaczewskaB Dybała

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