Use of Secondary Data to Estimate Instantaneous Model Parameters of Diabetic Heart Disease: Lemonade Method.

An International Journal on Information Fusion
Wen YeJacob Barhak

Abstract

With the increasing burden of chronic diseases on the health care system, Markov-type models are becoming popular to predict the long-term outcomes of early intervention and to guide disease management. However, statisticians have not been actively involved in the development of these models. Typically, the models are developed by using secondary data analysis to find a single "best" study to estimate each transition in the model. However, due to the nature of secondary data analysis, there frequently are discrepancies between the theoretical model and the design of the studies being used. This paper illustrates a likelihood approach to correctly model the design of clinical studies under the conditions where 1) the theoretical model may include an instantaneous state of distinct interest to the researchers, and 2) the study design may be such that study data can not be used to estimate a single parameter in the theoretical model of interest. For example, a study may ignore intermediary stages of disease. Using our approach, not only can we accommodate the two conditions above, but more than one study may be used to estimate model parameters. In the spirit of "If life gives you lemon, make lemonade", we call this method "Lemona...Continue Reading

References

Aug 1, 1985·Diabetes·G UlvenstamC Wilhelmsson
Aug 19, 2000·Hematology/oncology Clinics of North America·S D RamseyN Urban
Nov 29, 2001·Clinical Science·R J StevensUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Nov 6, 2002·Journal of Biomedical Informatics·Leonard Schlessinger, David M Eddy
Oct 28, 2003·Diabetes Care·William H Herman
Nov 25, 2005·Diabetes Care·Honghong ZhouWilliam H Herman
Jan 18, 2006·Statistics in Medicine·Deanna J M IsamanMorton B Brown
Jun 19, 2010·Journal of Biomedical Informatics·Jacob BarhakDonghee Lee

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Citations

Aug 8, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Pedro SaramagoAlex J Sutton
Jul 8, 2017·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Ieva Vasiljeva, Ognjen Arandjelović

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