PMID: 2451210Jan 1, 1988Paper

Use of selective toxins to separate surface and tubular sodium currents in frog skeletal muscle fibers

Pflügers Archiv : European journal of physiology
N ArispeE Rojas

Abstract

The interaction between toxin gamma from the venom of the scorpion Tityus serrulatus and sodium channels in skeletal muscle membranes from the frog Caudiverbera caudiverbera was studied. Sodium current from cut sartorius muscle fibers is a complex signal in which early and late components are difficult to separate. External application of Tityus gamma toxin initially blocked the early component in a voltage-dependent manner. Longer exposure to the toxin induced a complete blockade of the two components of the inward current. Application of tetrodotoxin to fibers pretreated with Tityus toxin at submaximal concentrations allowed the observation of the two distinct components of the inward current. Binding of 125I-labelled toxin to highly purified membrane fractions from the same muscle was used to establish the presence of high affinity receptors both in the transverse-tubular and in the surface membrane.

References

Dec 1, 1978·The Journal of General Physiology·J VergaraB M Salzberg
Mar 1, 1976·The Journal of General Physiology·B Hille, D T Campbell
Apr 1, 1976·The Journal of General Physiology·E JaimovichP Horowicz
Jan 1, 1985·Progress in Biophysics and Molecular Biology·J CailléO Rougier
Nov 1, 1973·The Journal of Physiology·R H Adrian, L D Peachey
Jul 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·N J ArispeL V Rojas
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E JaimovichM Lazdunski
Apr 1, 1983·Pflügers Archiv : European journal of physiology·E JaimovichO Rougier
Jan 1, 1980·Biophysical Journal·R E TaylorE Rojas

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Citations

Jan 29, 2005·British Journal of Pharmacology·Isaltino M ConceiçãoLúcia Garcez-do-Carmo

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