Use of sequence analysis of the P2 domain for characterization of norovirus strains causing a large multistate outbreak of norovirus gastroenteritis in Germany 2012

International Journal of Medical Microbiology : IJMM
Marina HöhneC-Thomas Bock

Abstract

Human norovirus is the main cause of non-bacterial gastroenteritis worldwide. It is transmitted from person to person, by fecally contaminated food or water or through virus containing aerosols originating during vomiting of infected persons. In September and October 2012, the largest foodborne norovirus outbreak in Germany so far spread over 5 Federal States (Berlin, Brandenburg, Saxony, Saxony-Anhalt, and Thuringia) affecting nearly 11,000 people mainly in schools and child care facilities. Epidemiological and trace-back investigations supported the assumption that a batch of frozen strawberries imported from China was the likely source of the outbreak. Sequence analysis of the capsid region encoding the P2 domain was used successfully for identification of transmission routes and epidemiologic relationship but was hampered by a lack of universal primers for all known genotypes so far. In the present study, a molecular approach was designed to track outbreak-related samples from the affected states of the large foodborne outbreak in Germany. Therefore, sequence analysis within the highly variable P2 domain of the capsid gene using newly developed universal P2 primers for genogroup I and genogroup II strains in combination wit...Continue Reading

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Citations

Sep 14, 2015·International Journal of Medical Microbiology : IJMM·Ulrich VogelMary Slack
Aug 2, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Aurora SabriàSusana Guix
Feb 10, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·S NiendorfC T Bock
Jul 26, 2017·Journal of Medical Microbiology·Leesa D BrugginkJohn A Marshall
Dec 10, 2016·Food and Environmental Virology·Simone Guadagnucci MorilloMaria do Carmo Sampaio Tavares Timenetsky
Oct 18, 2020·Viruses·Sandra NiendorfSonja Jacobsen

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