Use of serum biomarkers to predict cerebral hypoxia after severe traumatic brain injury

Journal of Neurotrauma
Deborah M SteinThomas M Scalea

Abstract

The management of severe traumatic brain injury (TBI) focuses on prevention and treatment of secondary insults such as cerebral hypoxia (CH). There are a number of biomarkers that are thought to play a part in secondary injury following severe TBI. This study evaluates the association between S100β, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP), detected in the serum of severe TBI patients and CH as measured by brain tissue oxygen partial pressure (Pbo(2)). Patients with severe TBI were prospectively enrolled. Pressure times time (PTD; mm Hg*h), measuring the depth and duration of CH, was calculated for 12-h periods for episodes of moderate (Pbo(2) < 20 mm Hg) and severe (Pbo(2) < 15 mm Hg) CH, and compared to serum levels of S100β, NSE, and GFAP drawn prior to periods of monitoring. An adjusted mixed model analysis was applied as was receiver operating characteristic (ROC) curve analysis. Of 76 patients enrolled, 24 had Pbo(2) monitoring. One hundred and thirty serum samples were matched with 12-h periods of monitoring. Significant associations were found in adjusted analyses between increasing serum levels of S100β (coefficient=0.57, 0.56; p<0.001), NSE (coefficient=0.48, 0.52; p<0.001), and GFAP (...Continue Reading

References

Dec 1, 1978·Journal of the Neurological Sciences·D I GrahamD Doyle
Jan 1, 1992·Scandinavian Journal of Thoracic and Cardiovascular Surgery·M SellmanB K Semb
Oct 1, 1991·European Journal of Clinical Investigation·R T CunninghamK D Buchanan
Jun 1, 1991·Molecular and Chemical Neuropathology·R DauberschmidtM Meyer
Jan 1, 1987·Annual Review of Neuroscience·P J Marangos, D E Schmechel
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Jan 1, 1996·The Annals of Thoracic Surgery·S WestabyE Ståhl
Apr 1, 1996·European Journal of Clinical Investigation·R T CunninghamK D Buchanan
Feb 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·P Martens
Jun 1, 1997·Neurological Research·K L KieningW R Lanksch
Jan 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·D F SignoriniJ D Miller
Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R AstudilloB Aberg
Feb 15, 2000·The Journal of Head Trauma Rehabilitation·D J ThurmanJ E Sniezek
Apr 14, 2000·Neurosurgery·W A van den BrinkA I Maas
Oct 19, 2000·Lancet·J Ghajar
Dec 2, 2000·Journal of the Neurological Sciences·J W EltingJ De Keyser
Feb 24, 2001·British Journal of Neurosurgery·I R ChambersA D Mendelow
Dec 17, 2002·Journal of Neurotrauma·J T L WilsonG M Teasdale
Feb 21, 2003·Intensive Care Medicine·Iwan A MeynaarDurk F Zandstra
May 7, 2004·The Journal of Trauma·Vicente H GraciasC William Schwab
Oct 30, 2004·The Journal of Trauma·D'Andrea K JosephThomas M Scalea
Apr 20, 2006·Journal of Neurosurgery·Bizhan AarabiHoward M Eisenberg
Sep 20, 2006·The Journal of Head Trauma Rehabilitation·Jean A LangloisMarlena M Wald
Nov 1, 2006·Current Medicinal Chemistry·Mark StroickMichael G Hennerici
Dec 5, 2006·Intensive Care Medicine·Stefanos KorfiasDamianos E Sakas
Mar 6, 2007·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ali TabibiAli R Niroomand
Dec 28, 2007·Journal of Neurotrauma·Rachel Pardes BergerP David Adelson
Apr 12, 2008·The Journal of Trauma·Isaac TawilThomas M Scalea
Oct 14, 2008·The Journal of Trauma·Kimberly M LumpkinsThomas Scalea
Feb 14, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Anthony A FigajiJonathan C Peter
Mar 5, 2009·Journal of Neurotrauma·Brian J BlythJeffrey J Bazarian

❮ Previous
Next ❯

Citations

Jul 20, 2013·Journal of Neuroinflammation·Donna M Wilcock, W Sue T Griffin
Mar 13, 2014·American Journal of Hypertension·Lina BergmanHelena Åkerud
Jul 16, 2014·Cancer Investigation·Ryan P LangeMatthias Holdhoff
May 16, 2015·Trends in Neurosciences·Zhihui Yang, Kevin K W Wang
May 29, 2013·CNS Neuroscience & Therapeutics·Shoji YokoboriRoss Bullock
Apr 15, 2016·Neurological Research·Ana Rodríguez-RodríguezFrancisco Murillo-Cabezas
Jun 20, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Nicole V TolanStefan K G Grebe
May 21, 2015·Arquivos de neuro-psiquiatria·Jun DingHengli Tian
Sep 14, 2018·The Journal of Trauma and Acute Care Surgery·Todd O McKinleyRichard B Rodgers
Dec 14, 2012·Expert Review of Clinical Pharmacology·Sabino ScollettaFabio Silvio Taccone
Aug 17, 2019·Journal of Neurotrauma·Sergio BagnatoGiuseppe Galardi
Mar 6, 2015·The Journal of Trauma and Acute Care Surgery·Bellal JosephPeter Rhee
Feb 26, 2016·The Journal of Trauma and Acute Care Surgery·Stephen S CaiDeborah M Stein
Jul 25, 2014·The Journal of Trauma and Acute Care Surgery·Cecilie Heerdegen JepsenPär I Johansson
Sep 9, 2016·Critical Care : the Official Journal of the Critical Care Forum·Eric Peter ThelinDavid W Nelson
Feb 19, 2014·Critical Care Medicine·Tatiana C Ciomartan
Feb 6, 2019·Frontiers in Neurology·Anelia A Y KassiShyam Gajavelli
Aug 25, 2017·Journal of Neuroscience Research·Bellal JosephPeter Rhee

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
enzyme-linked immunosorbent assay

Software Mentioned

SAS

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.