PMID: 1929277Jun 1, 1991

Use of slime dispersants to promote antibiotic penetration through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy
C A GordonC Marriott

Abstract

Agents with the potential to reduce Pseudomonas aeruginosa alginate viscosity (slime dispersants) were shown to promote the diffusion of antipseudomonal antibiotics through alginate but were more effective in facilitating the diffusion of gentamicin than that of ceftazidime. EDTA increased the diffusion rates of these antibiotics by factors of 4.0 and 1.5, respectively, although sodium chloride significantly reduced viscosity and enhanced gentamicin diffusion.

References

Nov 1, 1990·Antimicrobial Agents and Chemotherapy·H AnwarJ W Costerton
Oct 1, 1989·The Journal of Antimicrobial Chemotherapy·N BolisterC Marriott
May 1, 1989·Journal of General Microbiology·W W NicholsH L Walmsley
Nov 1, 1985·The Journal of Pharmacy and Pharmacology·J D Topham, G P Martin
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·W W NicholsH L Walmsley
Jan 1, 1987·Annual Review of Microbiology·J W CostertonT J Marrie
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·J C NickelJ W Costerton
Nov 1, 1982·The Journal of Antimicrobial Chemotherapy·M P Slack, W W Nichols
Nov 1, 1983·Reviews of Infectious Diseases·J R GovanN R Baker
Dec 1, 1981·The Journal of Infection·D Roberts, P Cole

Citations

Jan 1, 1996·Biofouling·I Foley, P Gilbert
Dec 1, 1992·The Journal of Applied Bacteriology·D G Allison, M J Matthews
May 28, 2013·Computational and Mathematical Methods in Medicine·Morgan B GiersMichael R Caplan
Oct 25, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Morgan B GiersRyan McLemore
Jun 9, 2009·Journal of Medical Microbiology·Mohan VenkateshJames Versalovic
Apr 28, 2012·Medical Hypotheses·Suzette V van der Waal, Lucas W M van der Sluis
Feb 8, 2006·European Journal of Oral Sciences·Iriana C J ZaninReginaldo B Gonçalves
Mar 24, 2012·Clinical Orthopaedics and Related Research·Morgan B GiersRyan McLemore

Related Concepts

Alginates
Antibiotics
Fortum
Chromatography, Affinity
Diffusion
Elasticity
Gel
Gentacycol
Polysaccharides, Bacterial
Pseudomonas aeruginosa

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