Use of specific antisera against leukemia-associated antigens in the diagnosis of childhood acute lymphoblastic leukemia

Acta Haematologica
B NetzelS Thierfelder

Abstract

A series of 66 children with acute lymphoblastic leukemia (ALL) at diagnosis were investigated (simultaneously) for various surface markers. For this purpose the reaction of specific antisera against ALL antigens and T cell antigens was analysed in every case by several test systems, namely immunofluorescence, microcytotoxicity and complement fixation. A clearly defined classification in 6 subgroups of ALL emerged. The clinical data at presentation and possible correlations with the immunological subgroups were demonstrated.

Related Concepts

Tumor Antigens
Surface Antigens
Complement Fixation Tests
Microcytotoxicity Test
Immunofluorescence Assay
Immune Sera
Lymphoid Leukemia
Receptors, Antigen, B-Cell
T-Lymphocyte

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