Use of specified critical periods of different congenital abnormalities instead of the first trimester concept

Birth Defects Research. Part A, Clinical and Molecular Teratology
A E CzeizelF Bánhidy

Abstract

Previously the first trimester, later the 2nd and/or 3rd gestational months were evaluated at the analysis of different exposures in different congenital abnormalities. However, different congenital abnormalities have different critical periods. The objective of this study was to check the feasibility of a new approach to consider the specified critical periods of different congenital abnormalities separately. The potential teratogenic effect of oral ampicillin treatment and maternal influenza/fever during the study pregnancy regarding any time in pregnancy, during the first trimester, in the 2nd and/or 3rd gestational months, and finally in the specified critical periods of given congenital abnormalities were evaluated in the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities. Of 22,843 cases, 1644 (7.2%) and 1328 (5.8%) were born to mothers who had oral ampicillin treatment or were affected with influenza/fever during the study pregnancy, while of 38,151 control newborns without any defect, 2631 (6.9 %) and 1838 (4.8%) had mothers with ampicillin treatment or influenza/fever, respectively. The analysis of different exposure time windows showed some difference in the r...Continue Reading

References

Feb 20, 1993·BMJ : British Medical Journal·A E CzeizelB Modell
Jun 21, 2001·Epidemiology·M RockenbauerUNKNOWN EuroMAP Group
Aug 3, 2001·American Journal of Obstetrics and Gynecology·A E CzeizelJ Olsen
Aug 6, 2003·Pharmacoepidemiology and Drug Safety·A E CzeizelP Vargha
Jul 12, 2005·International Journal of Medical Sciences·Ferenc BánhidyAndrew E Czeizel
Dec 3, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Nándor AcsAndrew E Czeizel

❮ Previous
Next ❯

Citations

May 31, 2014·BMJ : British Medical Journal·Francesco TrottaGiuseppe Traversa
Dec 25, 2013·Human Reproduction·J M LuteijnH Dolk
Dec 5, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Melinda Csáky-SzunyoghAndrew E Czeizel
Apr 13, 2010·Nutrition·Ferenc BánhidyAndrew E Czeizel
Oct 3, 2013·Obstetrics and Gynecology·Dana Meaney-DelmanDenise J Jamieson
Apr 24, 2010·Journal of Travel Medicine·Urban Hellgren, Lars Rombo
Apr 5, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Attila VereczkeyAndrew E Czeizel
Aug 21, 2013·American Journal of Medical Genetics. Part a·Melinda Csáky-SzunyoghAndrew E Czeizel
Mar 23, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Ferenc BánhidyAndrew E Czeizel
Dec 23, 2009·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Cátia Aline Silva SwertsMário Sérgio Oliveira Swerts
Sep 8, 2009·Proceedings. Biological Sciences·Hai-Lu You, Da-Qing Li
Jul 21, 2020·Birth Defects Research·John M Graham
May 29, 2015·American Journal of Medical Genetics. Part a·Ferenc BánhidyAndrew E Czeizel
May 23, 2014·Central European Journal of Public Health·Melinda Csáky-SzunyoghAndrew E Czeizel
Nov 3, 2010·Central European Journal of Public Health·Ferenc BánhidyAndrew E Czeizel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.