Use of SPME-HS-GC-MS for the analysis of herbal products containing synthetic cannabinoids.

Journal of Analytical Toxicology
Anderson O CoxJohn W Huffman

Abstract

The increasing prevalence and use of herbal mixtures containing synthetic cannabinoids presents a growing public health concern and legal challenge for society. In contrast to the plant-derived cannabinoids in medical marijuana and other cannabinoid-based therapeutics, the commonly encountered synthetic cannabinoids in these mendaciously labeled products constitute a structurally diverse set of compounds of relatively unknown pharmacology and toxicology. Indeed, the use of these substances has been associated with an alarming number of hospitalizations and emergency room visits. Moreover, there are already several hundred known cannabinoid agonist compounds that could potentially be used for illicit purposes, posing an additional challenge for public health professionals and law enforcement efforts, which often require the detection and identification of the active ingredients for effective treatment or prosecution. A solid-phase microextraction headspace gas chromatography-mass spectrometry method is shown here to allow for rapid and reliable detection and structural identification of many of the synthetic cannabinoid compounds that are currently or could potentially be used in herbal smoking mixtures. This approach provides a...Continue Reading

References

Feb 20, 2009·British Journal of Pharmacology·Roger G Pertwee
Nov 27, 2009·Expert Opinion on Therapeutic Patents·Ganesh A ThakurAlexandros Makriyannis
Feb 2, 2010·Forensic Science International : Synergy·Nahoko UchiyamaYukihiro Goda
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Feb 22, 2011·Drug Testing and Analysis·Simon Hudson, John Ramsey
Apr 13, 2011·The International Journal on Drug Policy·Paul I DarganDavid M Wood

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Citations

Nov 17, 2012·Life Sciences·Brian F ThomasMegan Grabenauer
Oct 23, 2012·The American Journal on Addictions·Adegboyega Oyemade
Aug 11, 2015·Forensic Toxicology·Akira NameraMasataka Nagao
May 16, 2014·Natural Product Reports·Giovanni AppendinoOrazio Taglialatela-Scafati

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