Use of statins and recurrence of atrial fibrillation after catheter ablation or electrical cardioversion. A systematic review and meta-analysis

Thrombosis and Haemostasis
Francesco DentaliLuigina Guasti


Statins have important pleiotropic effects and have been shown to reduce vascular inflammation. Some evidence suggests that statins may have a role in the primary prevention of atrial fibrillation (AF), whereas little is know on the role of statins in patients with existing AF. We performed a meta-analysis of the literature to assess the effect of statins on the recurrence of AF after electrical cardioversion or ablation. MEDLINE and EMBASE databases were searched up to January 2010. Relative risks (RR) and 95% confidence intervals (CIs) were then calculated and pooled using a random-effects model. Statistical heterogeneity was evaluated through the use of I² statistics. Sixteen studies were included in our systematic review. Statins did not reduce the risk of AF recurrence after ablation (four studies including 750 patients; RR, 1.04; 95% CI, 0.85-1.28, p=0.71; I² = 34%). Conversely, the use of statins was associated with a significantly reduced risk of AF recurrence after electrical cardioversion (12 studies including 1790 patients; RR, 0.78; 95% CI, 0.67-0.90, p=0.0003; I² = 34%). This reduction was not statistically significant when the analysis was restricted to randomised controlled trials (RCTs) only (five studies, 458 p...Continue Reading


Jul 31, 2013·Expert Review of Cardiovascular Therapy·Giuseppe StabileAntonio De Simone
Mar 8, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Hanney Gonna, Mark M Gallagher
Feb 14, 2019·Cardiovascular Diabetology·Andrea Maria MarescaColomba Falcone
Oct 13, 2017·PloS One·Luigina GuastiAlberto Passi


Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Dec 31, 1997·Circulation·R A O'Rourke
Oct 16, 2002·Circulation·David J Lefer
Dec 6, 2002·The New England Journal of Medicine·D G WyseAtrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators
Dec 6, 2002·The New England Journal of Medicine·Isabelle C Van GelderRate Control versus Electrical Cardioversion for Persistent Atrial Fibrillation Study Group
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 12, 2003·The New England Journal of Medicine·Elaine M HylekDaniel E Singer
Sep 27, 2003·Circulation Research·Steven P JonesEduardo Marbán
Nov 19, 2003·Circulation·Ronnier J AvilesMina K Chung
Dec 17, 2003·The American Journal of Cardiology·Yinong Young-XuShmuel Ravid
Jan 24, 2004·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Mina K Chung
Mar 17, 2004·The American Journal of Cardiology·Arnljot TveitLars Gullestad
Nov 24, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Thomas McGinnEvidence-Based Medicine Teaching Tips Working Group
Jun 25, 2005·European Heart Journal·Mads D M Engelmann, Jesper Hastrup Svendsen
Nov 10, 2005·European Heart Journal·Christopher J BoosGregory Y H Lip
Mar 3, 2006·The New England Journal of Medicine·Hakan OralFred Morady
May 9, 2006·The American Journal of Cardiology·M OzaydinAhmet Altinbas
Oct 24, 2006·The American Journal of Cardiology·Amaya García-FernándezJuan G Martínez
Apr 17, 2007·Journal of the American College of Cardiology·Tong LiuPanagiotis Korantzopoulos
Jun 27, 2007·Journal of Cardiovascular Electrophysiology·M Obadah Al ChekakieDavid J Wilber
Oct 31, 2007·American Heart Journal·Karin H HumphriesCARAF Investigators
Feb 26, 2008·Journal of the American College of Cardiology·Laurent FauchierDominique Babuty
May 9, 2008·Journal of Cardiovascular Electrophysiology·Matthew WrightPierre Jais
Dec 9, 2008·American Heart Journal·Shinya GotoREACH Registry Investigators
Jul 23, 2009·Annals of Internal Medicine·David MoherPRISMA Group

Related Concepts

Vascular Inflammations
Meta-Analysis (Publications)
Recurrent Malignant Neoplasm
Atrial Fibrillation
Vascular Diseases
Recurrence (Disease Attribute)
Electroversion Therapy
Catheter Ablation, Transvenous
Hydroxymethylglutaryl-CoA Reductase Inhibitors

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.