PMID: 3759260Jan 1, 1986Paper

Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis

International Archives of Allergy and Applied Immunology
M ChignardC Brange

Abstract

We presently demonstrate that PAF-acether (1-O-alkyl-2-O-acetyl-sn-glycerol-3-phosphoryl-choline) is formed by sensitized guinea pig lungs upon in vitro antigenic challenge. Pretreatment of the animals with a steroidal antiinflammatory drug, budesonide, almost totally suppresses this biosynthesis. Since budesonide inhibits the anaphylactic bronchoconstriction in actively sensitized guinea pigs, these data strongly support the assumption that PAF-acether is a mediator of bronchial anaphylaxis.

Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·M Andersson, U Pipkorn
Mar 1, 1991·The American Review of Respiratory Disease·C J Meade, H Heuer
May 1, 1991·Journal of Veterinary Internal Medicine·D D Morris
Nov 1, 1987·British Journal of Pharmacology·J RandonB B Vargaftig
Nov 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H O Heuer
May 1, 1989·Biochemical Pharmacology·M PretolaniB B Vargaftig

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.