Use of summary measures to adjust for informative missingness in repeated measures data with random effects

Biometrics
M C Wu, D A Follmann

Abstract

We discuss how to apply the conditional informative missing model of Wu and Bailey (1989, Biometrics 45, 939-955) to the setting where the probability of missing a visit depends on the random effects of the primary response in a time-dependent fashion. This includes the case where the probability of missing a visit depends on the true value of the primary response. Summary measures for missingness that are weighted sums of the indicators of missed visits are derived for these situations. These summary measures are then incorporated as covariates in a random effects model for the primary response. This approach is illustrated by analyzing data collected from a trial of heroin addicts where missed visits are informative about drug test results. Simulations of realistic experiments indicate that these time-dependent summary measures also work well under a variety of informative censoring models. These summary measures can achieve large reductions in estimation bias and mean squared errors relative to those obtained by using other summary measures.

Citations

Jan 10, 2002·Statistics in Medicine·Soomin ParkLei Shen
Feb 26, 2010·Journal of Biopharmaceutical Statistics·Fanhui KongKun Jin
Sep 17, 2002·Biometrics·David M Zucker, Jonathan Denne
Jul 19, 2005·Statistics in Medicine·Edward F VoneshMark D Schluchter
Jul 17, 1999·Statistics in Medicine·P S Albert
Apr 24, 2001·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·I R KatzM J Kallan
Feb 9, 2011·Statistical Methods in Medical Research·Paul S Albert, Joanna H Shih
Dec 14, 2004·Journal of Biopharmaceutical Statistics·Hong-Bin FangMing Tan
Jun 12, 2020·Statistical Methods in Medical Research·Hyoyoung Choo-WosobaPaul S Albert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.