Use of surface-enhanced Raman scattering as a prognostic indicator of acute kidney transplant rejection

Biomedical Optics Express
Jingmao ChiHenry Du

Abstract

We report an early, noninvasive and rapid prognostic method of predicting potential acute kidney dysfunction using surface-enhanced Raman scattering (SERS). Our analysis was performed on urine samples collected prospectively from 58 kidney transplant patients using a He-Ne laser (632.8 nm) as the excitation source. All abnormal kidney function episodes (three acute rejections and two acute kidney failures that were eventually diagnosed independently by clinical biopsy) consistently exhibited unique SERS spectral features in just one day following the transplant surgery. These results suggested that SERS analysis provides an early and more specific indication to kidney function than the clinically used biomarker, serum creatinine (sCr).

References

Feb 1, 1978·Annals of Surgery·S R PreviteS I Cho
Dec 16, 1998·Kidney International·R A Star
Mar 25, 2000·Mechanisms of Ageing and Development·Y LavrovskyA K Roy
May 10, 2001·Lasers in Surgery and Medicine·W R PremasiriM E Womble
Jan 28, 2003·Transplantation·Yvo W J SijpkensLeendert C Paul
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Augusta ArrudaAurélio V Graça-Souza
May 27, 2005·Toxicology Letters·Sanjay Kumar, Uday Bandyopadhyay
Oct 28, 2006·Annual Review of Physical Chemistry·Katherine A Willets, Richard P Van Duyne
Aug 6, 2009·Optics Express·Jonas BeermannSergey I Bozhevolnyi
Dec 17, 2010·Nephron. Clinical Practice·Nada AlachkarBernard G Jaar

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