Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle

Clinical and Diagnostic Laboratory Immunology
H Martin VordermeierR Glyn Hewinson

Abstract

In Great Britain an independent scientific review for the government has concluded that the development of a cattle vaccine against Mycobacterium bovis infection holds the best long-term prospect for tuberculosis control in British herds. A precondition for vaccination is the development of a complementary diagnostic test to differentiate between vaccinated animals and those infected with M. bovis so that testing and slaughter-based control strategies can continue alongside vaccination. To date bacillus Calmette-Guérin (BCG), an attenuated strain of M. bovis, is the only available vaccine for the prevention of tuberculosis. However, tests based on tuberculin purified protein derivative cannot distinguish between M. bovis infection and BCG vaccination. Therefore, specific antigens expressed by M. bovis but absent from BCG constitute prime candidates for differential diagnostic reagents. Recently, two such antigens, ESAT-6 and CFP-10, have been reported to be promising candidates as diagnostic reagents for the detection of M. bovis infection in cattle. Here we report the identification of promiscuous peptides of CFP-10 that were recognized by M. bovis-infected cattle. Five of these peptides were formulated into a peptide cocktail...Continue Reading

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Citations

Sep 17, 2009·Tropical Animal Health and Production·Gobena AmeniMartin Vordermeier
Jun 14, 2012·Journal of Microbiological Methods·Sugumar ParthasarathyVilluppanoor Alwar Srinivasan
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Jul 2, 2010·Journal of Clinical Microbiology·Adam O WhelanMartin H Vordermeier
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