Use of teriparatide in osteoporotic fracture patients

Injury
Cory Collinge, Juan Favela

Abstract

Teriparatide [PTH (1-34)] is a genetically engineered analog of human parathyroid hormone that acts as an anabolic drug by increasing activity in both osteoblasts and osteoclasts. Intermittent (once-daily) doses of teriparatide seem to stimulate osteoblast activity and therefore result in a net increase of bone formation. It is recommended for use in post-menopausal women (PMW), men with hypogonadal osteoporosis, as well as men and women with glucocorticoid-induced osteoporosis. In vivo studies have generated important findings regarding teriparatide's role in the enhancement of fracture healing. The intention of this article is to review the clinical findings of teriparatide to stimulate fracture healing. The drug was shown in a prospective randomized, double blind study to achieve earlier radiographic cortical bridging of three of four cortices (7.4 weeks) compared to patients who were assigned to the placebo group (9.1 weeks). Another study compared mean time for healing and functional outcome in two groups of elderly women who had suffered osteoporotic pelvic fractures: one group received daily 100 μg parathyroid hormone (1-84) injections, while the other group received no treatment. Patients who received the PTH (1-84) inj...Continue Reading

References

Jul 29, 2003·Cleveland Clinic Journal of Medicine·Chad Deal, James Gideon
Apr 5, 2005·The Journal of Bone and Joint Surgery. American Volume·Yaser M AlkhiaryThomas A Einhorn
Mar 18, 2009·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Cara A CiprianoJoseph M Lane
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Per AspenbergMark C Lakshmanan
Sep 15, 2011·The Journal of Bone and Joint Surgery. American Volume·Peter PeichlGerold Holzer

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Citations

Apr 24, 2019·Artificial Organs·Emrah YucesanErhan Aysan
Jun 3, 2016·Der Internist·B Harbeck, H Lehnert
Mar 31, 2021·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Jihyo HwangJoshua A Parry
Jun 29, 2016·Journal of the American Medical Directors Association·Gustavo DuqueCharles A Inderjeeth
Aug 26, 2021·Curēus·Panagiotis DrakopoulosChristos Zafeiris

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