PMID: 7336191Jan 1, 1981Paper

Use of the activated coagulation time in cardiac surgery. Effects on heparin-protamine dosages and bleeding

Scandinavian Journal of Thoracic and Cardiovascular Surgery
C Papaconstantinou, K Rådegran

Abstract

A standard heparin-protamine protocol was used for a series of 44 patients. In a second series of 82 patients. Activated Clotting Time (ACT) by the Hemochron method was used to control heparinization and its reversal with protamine. The two groups was similar in regard to surgical procedures, pump-times and perfusion technique. Patients in group II controlled by Hemochron received in average 13% less heparin and 48% less protamine than patients in group 1 (p less than 0.001 Student's t-test). The intra-operative blood loss was on an average 50% less in group II than in group I (p less than 0.001). There was, however, no significant difference in regard to postoperative bleeding. The introduction of the ACT test thus resulted in reduced dosages of heparin and protamine and in a reduction of intra-operative bleeding, while surgical technique seems to be the main factor in the control of postoperative bleeding.

References

Feb 1, 1974·The Annals of Thoracic Surgery·J D HillC H Mielke
May 2, 1966·JAMA : the Journal of the American Medical Association·P G Hattersley

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Citations

Dec 17, 2009·British Journal of Anaesthesia·L J Enriquez, L Shore-Lesserson
Oct 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·J BoldtG Hempelmann
Jan 1, 1984·Scandinavian Journal of Thoracic and Cardiovascular Surgery·S OttesenK Hatteland
Nov 15, 2013·Circulation·Therese M GigliaUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council
Dec 1, 1996·Anesthesia and Analgesia·T AmmarB S Coller
Feb 15, 2013·Anesthesia and Analgesia·Alan Finley, Charles Greenberg
May 21, 2016·The International Journal of Artificial Organs·Osamu MaruyamaYoshiyuki Taenaka

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