Use of the argyrophilic nucleolar region method for cytologic and histologic examination of the lymph nodes in dogs

Veterinary Pathology
P VajdovichE Perge

Abstract

Argyrophilic nucleolar organizer region (AgNOR) counts in cytologic and histologic lymph node samples from healthy dogs and dogs with lymphoma were compared. Control samples were taken from 10 Beagle dogs (six female and four male dogs, 1.5-2 years), and lymphoma samples were taken from 16 dogs. Cytologic samples were obtained by fine-needle aspiration and impression and histologic samples by excision or incisional biopsy. Altogether, 26 cytologic, 19 excisional, and 7 incisional biopsy samples were examined. Lymph nodes of controls showed a moderate inflammatory pattern; of the lymphoma cases, nine were low-grade forms and seven were high-grade forms. Mean AgNOR counts per nucleus were determined. AgNOR counts were statistically different (P < 0.001) between controls and lymphoma cases in cytologic (1.35 and 3.59, respectively) and histologic (1.4 and 2.89, respectively) samples. In lymphoma cases, AgNOR counts in cytologic samples were higher than those in histologic samples by 0.81 (P < 0.001) and showed a linear relationship (r = 0.6; P < 0.05) with the histologic counterparts in excisional biopsy samples. AgNOR counts in low- and high-grade lymphomas were significantly different (P < 0.05) in cytologic (3.21 and 4.08, resp...Continue Reading

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Citations

Mar 10, 2016·The Veterinary Quarterly·M Zandvliet
Aug 17, 2017·Anais Da Academia Brasileira De Ciências·Vanessa S A GosslerInes C Giometti

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