PMID: 9002562Jan 1, 1997Paper

Use of the combination of myoglobin and CK-MB mass for the rapid diagnosis of acute myocardial infarction

The American Journal of Emergency Medicine
M C KontosR L Jesse

Abstract

Early identification of patients presenting with myocardial infarction (MI) is necessary for rapid initiation of treatment. Currently, MI has been diagnosed using the combination of the history, electrocardiogram (ECG), and biochemical markers of myocardial necrosis. Unfortunately, all lack sufficient sensitivity and specificity to confidently identify most patients with MI in a timely enough fashion to influence early intervention. Development of newer immunochemical assays for CK-MB mass and myoglobin have allowed for earlier, more rapid diagnosis; however, each has important limitations. The diagnostic sensitivity of CK-MB mass, myoglobin, and the combination of both were analyzed at the time of presentation (0 hours) and again 4 hours later in 101 patients admitted from the emergency department (ED) with possible MI. Twenty patients were subsequently diagnosed as having MI. The sensitivity of the initial ECG was 60%, compared with the sensitivities of the initial myoglobin and CK-MB mass of 70% and 30%, respectively. By 4 hours the sensitivity of myoglobin had increased to 85% and CK-MB mass to 90%. The combination of the initial myoglobin and CK-MB mass had a sensitivity of 85%. Combining these two markers, using both the ...Continue Reading

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Citations

Oct 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·A H WuL Graff
Feb 24, 2001·Emergency Medicine Clinics of North America·B J O'Neil, M A Ross
Nov 25, 2000·Journal of the American College of Cardiology·M C KontosR L Jesse
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·J Mair
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·M PanteghiniG Bonetti
Feb 22, 2012·International Journal of Cardiology·Sally J Aldous
Apr 13, 2010·The Medical Clinics of North America·Anthony F T BrownMartin Than
Nov 10, 2005·Cardiology Clinics·Andra L Blomkalns, W Brian Gibler
Oct 12, 2010·American Heart Journal·Willibald HochholzerRobert P Giugliano
May 25, 1999·The American Journal of Emergency Medicine·I A KhanT J Sacchi
Mar 12, 1999·The American Journal of Cardiology·M C KontosR L Jesse
May 26, 2001·Emergency Medicine Clinics of North America·C A Ghaemmaghami, W J Brady
Dec 6, 2005·Angiology·Medha Rajappa, Alpana Sharma
May 9, 2002·Mass Spectrometry Reviews·N B Cech, C G Enke
Jun 5, 2004·Progress in Cardiovascular Diseases·Andra L Blomkalns, W Brian Gibler

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