Use of the combined first-trimester screen result and low PAPP-A to predict risk of adverse fetal outcomes

Prenatal Diagnosis
Sandie L BarrettNarelle C Hadlow

Abstract

To investigate associations between combined first-trimester screen result, pregnancy associated plasma protein-A (PAPP-A) level and adverse fetal outcomes in women. Pregnancy outcomes for 10,273 women participating in a community based first-trimester screening (FTS) programme in Western Australia were ascertained by record linkage to birth and birth defect databases. A first-trimester risk cut-off of > or = 1 in 300 defined screen positive women. Screen positive pregnancies were more likely to have Down syndrome and birth defects (chromosomal or nonchromosomal) than screen negative pregnancies. When birth defects were excluded, screen positive pregnancies were at increased risk of pregnancy loss, low birth weight and preterm birth. Pregnancies with low PAPP-A (< or =0.3 multiples of the median (MoM)) had higher risk of chromosomal abnormality, birth defect, preterm birth, low birth weight, or pregnancy loss, compared to those with PAPP-A > 0.3 MoM. In pregnancies without birth defects, low PAPP-A was a stronger predictor of preterm birth, low birth weight or pregnancy loss than a screen positive result. Women with positive screen or low PAPP-A were at increased risk for some adverse fetal outcomes. The sensitivity of these pa...Continue Reading

References

May 26, 1999·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K SpencerK H Nicolaides
Dec 15, 2000·Journal of Paediatrics and Child Health·C BowerE Rudy
Aug 8, 2001·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A P SoukaK H Nicolaides
Aug 9, 2001·Prenatal Diagnosis·Y OchshornY Yaron
Sep 12, 2002·Prenatal Diagnosis·Yuval YaronAvi Orr-Urtreger
Oct 10, 2003·The New England Journal of Medicine·Ronald WapnerUNKNOWN First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group
Dec 31, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C-C ChengM-S Tsai
Jan 10, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Michele Kwik, Jonathan Morris
Apr 22, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Genc KabiliPaul Bischof
Oct 28, 2004·American Journal of Obstetrics and Gynecology·David KrantzUNKNOWN First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group
Nov 19, 2004·Acta Obstetricia Et Gynecologica Scandinavica·Silvia So-Aei LiuSu-Chee Chen
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Kyriaki AvgidouKypros H Nicolaides
Oct 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Narelle C HadlowCarol Bower
Apr 4, 2006·Obstetrics and Gynecology·Peter O'LearyRosanne Stock

❮ Previous
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Citations

Dec 1, 2009·Human Reproduction·Jenni K RantaSeppo Heinonen
Jul 11, 2009·BMC Medical Research Methodology·Samantha J LainChristine L Roberts
Mar 20, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Stephan von HaehlingBoris Bigalke
Feb 20, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Shridevi GunduPrakash Gambhir
Jun 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet Fatih KarsliMustafa Ugur
Jul 3, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet Fatih KarsliTuncay Kucukozkan
Dec 12, 2013·Expert Review of Cardiovascular Therapy·Goran Loncar, Stephan von Haehling
Jul 2, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Fergus ScottAndrew McLennan
Jan 10, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Kate J BrameldRosanne Stock
Sep 23, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·A Conde-AgudeloA T Papageorghiou
Aug 19, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jennifer L CohenJoanne L Stone
Jul 13, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Niels Tørring
Oct 18, 2016·Prenatal Diagnosis·Marja KaijomaaVedran Stefanovic
Jan 19, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Marja KaijomaaVedran Stefanovic
May 4, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Eita Goto
Jun 25, 2015·Clinical Medicine Insights. Reproductive Health·Anna YliniemiMarkku Ryynanen
Apr 25, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D A Nyberg
Feb 27, 2009·Prenatal Diagnosis·Karen ChongDavid Chitayat
Jan 21, 2010·Prenatal Diagnosis·Katherine R GoetzingerAnthony O Odibo
Feb 7, 2014·Obstetrics and Gynecology·Rebecca J BaerLaura L Jelliffe-Pawlowski
Jan 1, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gökhan TosunSabahattin Altunyurt
Mar 17, 2015·The Journal of Obstetrics and Gynaecology Research·Sangeeta GuptaSeema Kapoor
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Sep 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·William P MarinelloLiping Feng
Apr 27, 2011·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E FilippiA L David
Jul 31, 2018·Disease Markers·Helena C BartelsDonal J Brennan
Feb 1, 2012·Australasian Journal of Ultrasound in Medicine·Harmonie LauTalat Uppal

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