Use of the cumulative proportion of responders analysis graph to present pain data over a range of cut-off points: making clinical trial data more understandable

Journal of Pain and Symptom Management
John T FarrarMitchell B Max

Abstract

In randomized controlled trials, no single definition of response is ideal for all purposes. We propose a method to present in a simple fashion the likelihood of response over a full range of response levels, which will facilitate a better understanding of clinical trial data. We present the technique called the cumulative proportion of responders analysis (CPRA) and its application to four pain clinical trial data sets as examples. The CPRA can be used to present the proportion of responders over the entire range of possible cut-off points as a graph. This allows the reader to compare treatment groups at any responder level that is valid for their patient population. Whether as a primary or secondary approach to a clinical trial of pain therapy, the display of data in a CPRA format may be useful in the understanding of results and applicability to patient care.

References

May 7, 1992·The New England Journal of Medicine·M B MaxR Dubner
Feb 18, 1995·BMJ : British Medical Journal·R J Cook, D L Sackett
Nov 1, 1996·Journal of Clinical Epidemiology·D A RedelmeierR S Goldstein
May 1, 1997·Annals of Internal Medicine·H J McQuay, R A Moore
Jun 28, 2000·The Clinical Journal of Pain·J T Farrar

❮ Previous
Next ❯

Citations

Mar 1, 2012·Der Schmerz·C Maier, R Baron
Oct 28, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Andrew G BushmakinAlesia Sadosky
Aug 8, 2008·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Patrick J LaRicciaJoseph J Gallo
Apr 16, 2010·The Clinical Journal of Pain·Sebastiano MercadanteAlessandra Casuccio
Aug 24, 2013·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Lan X ChenJohn T Farrar
Mar 31, 2012·Addiction Biology·Raye Z LittenAntonio Noronha
Jan 15, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Nicholas HenschkeRaymond W G Ostelo
Apr 12, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Lori D McLeodRon D Hays
Dec 25, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Thomas M AtkinsonEthan Basch
Nov 6, 2012·Academic Radiology·Demissie Alemayehu, Kelly H Zou
Nov 27, 2010·Journal of Clinical Epidemiology·Adeline Ruyssen-WitrandPhilippe Ravaud
Aug 1, 2015·The Journal of the American Dental Association·Marcelo W B AraujoJohn C Gunsolley
Dec 19, 2015·Statistics in Medicine·Thomas Permutt
Jul 29, 2008·Journal of Pain and Symptom Management·Phillip I Good
Dec 7, 2007·The Journal of Pain : Official Journal of the American Pain Society·Robert H DworkinStojan Zavisic
Jun 23, 2007·Journal of Pain and Symptom Management·Francis BurchSylvie Bouchard
Jun 25, 2009·Pain Practice : the Official Journal of World Institute of Pain·Joseph C CappelleriAlesia Sadosky
Oct 5, 2010·Journal of Oral Rehabilitation·J A Haythornthwaite
Nov 1, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Karsten FoghBo Jørgensen
May 21, 2011·European Journal of Pain : EJP·Robert FroudMartin Underwood
Jun 6, 2014·International Journal of Clinical Practice·S A KaplanUNKNOWN Assessment of Fesoterodine after Tolterodine ER (AFTER) Study Group
Nov 10, 2011·Upsala Journal of Medical Sciences·Magnus PetersonKurt Svärdsudd
Oct 18, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Birgitta Johansson Cahlin, Lars Dahlström
Sep 26, 2013·Pain·Marco PappagalloPaolo L Manfredi
Mar 8, 2013·PloS One·Hana M DobrovolnyCatherine A A Beauchemin
Aug 16, 2016·Pharmaceutical Statistics·Thomas Permutt, Feng Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.