Use of the egg-share model to investigate the paternal influence on fertilization and embryo development after in vitro fertilization and intracytoplasmic sperm injection

Fertility and Sterility
Denny SakkasK Sharif

Abstract

To investigate whether sperm from different males can influence fertilization and embryo development. To use an egg-sharing model, in which the eggs from one woman are shared between herself and a recipient, and different spermatozoa are used to fertilize the eggs. Assisted Conception Unit, Birmingham Women's Hospital, Edgbaston, United Kingdom. Infertile women undergoing egg sharing. In vitro fertilization (IVF). Fertilization rates and the mean day 2 or 3 embryo score (cell number X grade) were examined for egg-sharing pairs. A comparison was also made for pairs in which intracytoplasmic sperm injection (ICSI) and IVF was used as the insemination method. A paired samples t-test was used to compare the sharer and recipient results. Pregnancy rates did not differ between sharer and recipient couples. Interestingly, when comparing fertilization, there was a significant difference (P<.05) in favor of IVF over ICSI. When comparing embryo development between egg-sharing pairs, we found that approximately 30% of patients showed a difference in mean embryo score of >or= 5 in all embryo development and 14% in the quality of embryos available for transfer. We showed that the egg-sharing model is a successful alternative for the treatme...Continue Reading

References

Jan 27, 1998·British Journal of Obstetrics and Gynaecology·K SharifM Afnan
Oct 26, 1999·The Journal of Experimental Zoology·A Ahmadi, S C Ng
Nov 26, 1999·Human Reproduction·M BonduelleA Van Steirteghem
Jun 9, 2000·International Journal of Andrology·M H Brinkworth
Mar 8, 2002·The New England Journal of Medicine·Michèle HansenSandra Webb
Mar 19, 2002·Human Fertility : Journal of the British Fertility Society·W Chris L Ford
May 23, 2002·American Journal of Human Genetics·Gerald F CoxBernhard Horsthemke
Nov 20, 2002·American Journal of Human Genetics·Michael R DeBaunAndrew P Feinberg
Jan 14, 2003·Fertility and Sterility·Efstratios M KolibianakisPaul Devroey
Jan 15, 2003·Journal of Medical Genetics·E R MaherM M Hawkins
May 17, 2003·Fertility and Sterility·Ashok AgarwalMohamed A Bedaiwy
Oct 9, 2007·Human Reproduction·Sarah BowdinWilliam Reardon

❮ Previous
Next ❯

Citations

Feb 18, 2011·Journal of Assisted Reproduction and Genetics·Armand ZiniNaif Al-Hathal
May 5, 2005·Current Opinion in Obstetrics & Gynecology·Marcello SpanoDenny Sakkas
Dec 27, 2011·Reproductive Biomedicine Online·Maria GoudakouYannis Prapas
Jan 30, 2018·Clinical and Experimental Reproductive Medicine·Hwa Young ChoiByung Chul Jee
May 28, 2005·Human Reproduction·Michael S NealWarren G Foster
Jun 24, 2006·Current Opinion in Obstetrics & Gynecology
Jun 14, 2005·Reproductive Biomedicine Online·Andrea BoriniGiovanni Coticchio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.