Use of the Living Kidney Donor Profile Index in the Canadian Kidney Transplant Recipient Population: A Validation Study

Canadian Journal of Kidney Health and Disease
Mohamed ShantierSunita K Singh

Abstract

The Living Kidney Donor Profile Index (LKDPI) was derived in a cohort of kidney transplant recipients (KTR) from the United States to predict the risk of total graft failure. There are important differences in patient demographics, listing practices, access to transplantation, delivery of care, and posttransplant mortality in Canada as compared with the United States, and the generalizability of the LKDPI in the Canadian context is unknown. The purpose of this study was to externally validate the LKDPI in a large contemporary cohort of Canadian KTR. Retrospective cohort validation study. Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. A total of 645 adult (≥18 years old) living donor KTR between January 1, 2006 and December 31, 2016 with follow-up until December 31, 2017 were included in the study. The predictive performance of the LKDPI was evaluated. The outcome of interest was total graft failure, defined as the need for chronic dialysis, retransplantation, or death with graft function. The Cox proportional hazards model was used to examine the relation between the LKDPI and total graft failure. The Cox proportional hazards model was also used for external validation and performance assessment ...Continue Reading

References

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Citations

Jun 10, 2021·Canadian Journal of Kidney Health and Disease·Amanda J VinsonKarthik K Tennankore
Jun 25, 2021·World Journal of Transplantation·Mahmoud M MohamedKarim M Soliman

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