Use of the LMA-ProSeal in an experimental pig model -- a potential animal model for laryngeal mask airway research: results of a pilot study

Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
Kai GoldmannHinnerk Wulf

Abstract

In light of the increased use of the LMA-ProSeal (P-LMA) it seems desirable to consider the P-LMA for prolonged surgical cases or post-operative ventilation. Long-term use could carry the risk of serious complications. An experimental pig model could be used to gain basic knowledge about long-term use before conducting clinical trails. In this randomized controlled study we tested the hypothesis if prolonged positive pressure ventilation (PPV) with the P-LMA in the pig is possible. The P-LMA was used for airway maintenance under general anaesthesia and PPV in 15 German country pigs. Randomised into 3 groups, the animals were ventilated for 90, 150 and 390 minutes, respectively. Arterial blood gas measurements were used to determine adequacy of ventilation. Airway leak pressure (P (leak)) and maximum tidal volume (TV) were measured in the supine, lateral and prone positions. A bronchoscopic examination was performed to detect signs of aspiration. Adequate ventilation was demonstrated both after 120 min (4.7 +/- 0.4 kPa) and 360 min (4.7 +/- 0.5 kPa). The corresponding PaO(2) at FiO(2) = 1.0 was 59 +/- 5 kPa and 64 +/- 10 kPa, respectively. The mean P (leak) was 34 +/- 7 cm H(2)O. Change of position did not result in any signific...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.