Use of the novel combined contraceptive vaginal ring NuvaRing for ovulation inhibition

Fertility and Sterility
T M Mulders, T O Dieben

Abstract

To assess the effects of the combined contraceptive vaginal ring NuvaRing on ovarian function. Randomized, open-label, crossover study. Clinical pharmacology unit. Sixteen healthy female volunteers. Group 1: one cycle of combined oral contraceptive containing desogestrel (150 microg) and ethinyl estradiol (30 microg) (desogestrel/EE COC), followed by a NuvaRing treatment period. Group 2: NuvaRing treatment period followed by a cycle of desogestrel/EE COC. Follicular diameter, serum hormone concentrations (follicle-stimulating hormone, 17beta estradiol, luteinizing hormone, and progesterone), and endometrial thickness. NuvaRing use for the recommended period of 3 weeks resulted in complete inhibition of ovulation, as assessed by vaginal ultrasound (follicular diameter) and by serum luteinizing hormone and progesterone concentrations. Inhibition of ovulation was maintained for an additional 2 weeks of NuvaRing use. Ovarian suppression between the groups was comparable. Furthermore, ovarian suppression after 3 weeks of NuvaRing use was comparable to that on day 21 of DGS/EE COC intake. NuvaRing was well tolerated. NuvaRing completely inhibited ovulation throughout the normal 3-week period and the extended period of use. Ovarian su...Continue Reading

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