Use of the odds ratio to translate neuropsychological test scores into real-world outcomes: from statistical significance to clinical significance

Journal of Clinical and Experimental Neuropsychology
L A BieliauskasB L Roper

Abstract

Standard parametric tests generate p values and effect sizes, but often these are difficult to translate into real-world outcomes. In this study, the odds ratio was applied to neuropsychological testing and was compared to parametric approaches. Participants were 26 community-dwelling adults with possible or probable Alzheimer's disease and 25 matched healthy community-dwelling volunteers. Odds ratios were computed to estimate the probability of concurrent diagnosis given neuropsychological performance level. Odds ratios discriminated the groups at magnitudes that could not be discerned from t-test significance tables. These values were compared to sensitivity, specificity, and overall accuracy. Clinical and research applications and implications were addressed.

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Oct 12, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Robert J Frerichs, Holly A Tuokko
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