PMID: 375637Apr 1, 1979Paper

Use of the passive hemagglutination inhibition reaction for the purpose of determining the antigenic activity of anatoxins in vitro

Zhurnal mikrobiologii, epidemiologii, i immunobiologii
I V VorontsovS A Besova

Abstract

The work deals with the study of the possibility of using the passive hemagglutination inhibition test (antibody neutralization) for the determination of the antigenic activity of botulinum toxoids, types A, B and E. Erythrocytic diagnostic preparations were shown to allow the determination of up to 0.1 g of antigen. At the same time in vitro determinations were found to satisfactorily correlate with the results of in vivo determinations of the antigenic activity of these toxoids in the antitoxin-fixation test.

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