PMID: 8971652Nov 1, 1996Paper

Use of the polymeric matrix as internal standard for quantitation of in vivo delivery of tetracycline HCl from Actisite tetracycline fiber during periodontal treatment

Journal of Periodontal Research
J M LitchT L Burkoth

Abstract

Actisite (tetracycline hydrochloride) periodontal fiber is a 23 cm monofilament containing 12.7 mg tetracycline HCl homogeneously dispersed in a polymer. This product is indicated as an adjunct to scaling and root planing to reduce pocket depth and bleeding on probing in patients with adult periodontitis. The sustained-release system, placed in the periodontal pocket for 10 d, releases the antibiotic through mechanisms of diffusion and osmosis. A study was conducted in 13 patients with moderate to severe adult periodontitis to evaluate the amount of tetracycline HCl released during therapy (based on residual drug content). Fibers placed in the pocket remained in place for an average of 9 d. Each patient had 1-4 teeth treated with fiber therapy. At the termination of therapy samples from 29 teeth were retrieved and analyzed. The amount of matrix polymer was used as an internal standard for the quantitation of tetracycline, eliminating any uncertainties with respect to recovery or contamination. An average of 31% (SD 9%) of the tetracycline HCl content was released from the fiber during the treatment period. No single fiber had less than 50% of the original drug remaining. The study demonstrated that a substantial amount of the t...Continue Reading

References

Oct 1, 1992·Journal of Periodontology·J W RapleyD R Williams
Jul 1, 1990·Journal of Periodontal Research·M TonettiJ M Goodson
Nov 1, 1985·Journal of Periodontology·J M GoodsonS L Dunham
May 1, 1985·Journal of Periodontology·J M GoodsonP E Hogan
Nov 1, 1985·Journal of Periodontology·J M GoodsonS L Dunham

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Citations

Jan 24, 2002·Biomaterials·Philippe GérentesAlain Domard
Dec 5, 1998·Journal of Clinical Periodontology·M S Tonetti
Jul 1, 2004·Journal of Biomedical Materials Research. Part a·Kenya Whitaker-Brothers, Kathryn Uhrich
Dec 23, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yun-Chu ChenYoon Yeo
Jan 22, 2010·Journal of Pharmaceutical Sciences·Martin K McDermottCarolyn N Witkowski
Apr 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying WeiXing Tang

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