Use of the prognostic biomarker suPAR in the emergency department improves risk stratification but has no effect on mortality: a cluster-randomized clinical trial (TRIAGE III)

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Martin SchultzKasper Iversen

Abstract

Risk stratification of patients in the emergency department can be strengthened using prognostic biomarkers, but the impact on patient prognosis is unknown. The aim of the TRIAGE III trial was to investigate whether the introduction of the prognostic and nonspecific biomarker: soluble urokinase plasminogen activator receptor (suPAR) for risk stratification in the emergency department reduces mortality in acutely admitted patients. The TRIAGE III trial was a cluster-randomized interventional trial conducted at emergency departments in the Capitol Region of Denmark. Eligible hospitals were required to have an emergency department with an intake of acute medical and surgical patients and no previous access to suPAR measurement. Three emergency departments were randomized; one withdrew shortly after the trial began. The inclusion period was from January through June of 2016 consisting of twelve cluster-periods of 3-weeks alternating between intervention and control and a subsequent follow-up of ten months. Patients were allocated to the intervention if they arrived in interventional periods, where suPAR measurement was routinely analysed at arrival. In the control periods suPAR measurement was not performed. The main outcome was al...Continue Reading

Associated Clinical Trials

References

Sep 19, 2003·Journal of the American College of Cardiology·Giuseppe De LucaUNKNOWN ZWOLLE Myocardial Infarction Study Group
Jun 26, 2009·The New England Journal of Medicine·Warren J CantorUNKNOWN TRANSFER-AMI Trial Investigators
Jul 15, 2011·Resuscitation·Michael A PuskarichUNKNOWN Emergency Medicine Shock Research Network (EMSHOCKNET)
Aug 4, 2011·Scandinavian Journal of Public Health·Elsebeth LyngeMatejka Rebolj
Dec 29, 2011·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Ole KruseCharlotte Barfod
Dec 12, 2012·Annals of Emergency Medicine·Benjamin C SunSteven M Asch
Apr 10, 2013·Journal of Critical Care·Christopher W SeymourMargaret S Pepe
Jul 19, 2013·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christian H NickelRoland Bingisser
Dec 21, 2013·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Eileen J CarterElaine L Larson
Jun 3, 2014·BMC Medicine·Kasper IversenLars Køber
Jul 30, 2014·American Heart Journal·Erik KjøllerUNKNOWN CLARICOR Trial Group
Mar 19, 2015·Maturitas·Sonia CabrerizoVincenzo Malafarina
Oct 30, 2015·Critical Care : the Official Journal of the Critical Care Forum·Philipp SchuetzUNKNOWN TRIAGE Study group
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jan 14, 2017·Critical Reviews in Clinical Laboratory Sciences·S DesmedtM M Speeckaert

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Citations

Jun 13, 2020·Expert Review of Molecular Diagnostics·Ellen HaagPhilipp Schuetz
Jun 7, 2020·Critical Care : the Official Journal of the Critical Care Forum·Charalampos PierrakosJean-Louis Vincent
May 3, 2019·Journal of Clinical Microbiology·Ian L GunsolusNathan A Ledeboer
Apr 30, 2020·Intensive Care Medicine·David T Huang, Paula Ramirez
Jul 1, 2020·Frontiers in Cell and Developmental Biology·Esben IversenJesper Eugen-Olsen
Dec 18, 2019·Clinical Biochemistry·Rasmus Roenhoej RønhøjKasper Iversen
Jun 23, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Ankita SharmaSangeeta Choudhury

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