PMID: 16509525Mar 3, 2006Paper

Use of the recombinant human TSH stimulated thyroglobulin level and diagnostic whole body scan in children with differentiated thyroid carcinoma

Journal of Pediatric Endocrinology & Metabolism : JPEM
Francis M HoeThomas Moshang

Abstract

The recombinant human thyrotropin (TSH) (rhTSH) stimulated thyroglobulin (Tg) level is a useful tumor marker for disease surveillance in adults with differentiated thyroid carcinoma (DTC). We report our institution's experience using rhTSH in children. Seven children with DTC on thyroid hormone suppressive therapy after total thyroidectomy and radioablation received rhTSH (0.9 mg i.m.) on day 1 and 2. TSH rose to 224 +/- 93 mIU/l on day 2 and 13 +/- 5 mIU/l on day 5. Serum Tg level and diagnostic whole body radioiodine scan (DxWBS) were assessed on day 5. Five children were disease free: all had negative DxWBS; two had Tg < or = 2.1 ng/ml; two had anti-Tg antibodies; and one had no Tg measured. Two children had recurrent disease: one had a negative DxWBS and Tg of 15 ng/ml; and one had a positive DxWBS and no Tg measured. There were no adverse effects from rhTSH. These results suggest that rhTSH can be safely used for disease surveillance in children with DTC.

References

Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Wellington Hung, Nicholas J Sarlis
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·E L MazzaferriA Pinchera
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Richard J Robbins, Anne K Robbins
Jul 12, 2003·Thyroid : Official Journal of the American Thyroid Association·Alessandro AntonelliEle Ferrannini

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Citations

Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Catherine Dinauer, Gary L Francis
Sep 24, 2009·The Journal of Clinical Endocrinology and Metabolism·Markus LusterUNKNOWN Pediatric rhTSH Investigators Group
Jul 12, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Praveen KumarChandrasekhar Bal

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