PMID: 8937893Nov 1, 1996Paper

Use of the Syrian hamster embryo cell transformation assay for determining the carcinogenic potential of heavy metal compounds

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
G A KerckaertR J Isfort

Abstract

Cobalt sulfate hydrate, gallium arsenide, molybdenum trioxide, vanadium pentoxide, and nickel sulfate heptahydrate were tested in the Syrian hamster embryo (SHE) assay in order to increase the SHE assay database for heavy metals. All five compounds produced significant morphological transformation at one or more doses in a dose-responsive manner. Cobalt sulfate hydrate, gallium arsenide, molybdenum trioxide, and nickel (II) sulfate heptahydrate were all positive with a 24-hr exposure, suggesting direct DNA perturbation. Vanadium pentoxide was negative with a 24-hr exposure, but positive with a 7-day exposure. This pattern of response (24-hr SHE negative/7-day SHE positive) has been seen with other chemicals which have tumor promotion-like characteristics. Since the inception of the use of the SHE cell transformation assay for detecting the neoplastic transformation potential of chemicals, over 42 heavy metal compounds have been tested in this assay. Based on the 24 metal compounds which have been tested in the SHE, Salmonella, and some type of rodent bioassay, the SHE assay is 92% concordant with rodent bioassay carcinogenicity results, including a sensitivity of 95% (21/22) and a specificity of 50% (1/2). At this time, the mea...Continue Reading

Citations

Dec 4, 2003·Mutation Research·Kazimierz S KasprzakKonstantin Salnikow
Mar 30, 2002·Critical Reviews in Oncology/hematology·E Denkhaus, K Salnikow
Jul 23, 1999·Mutation Research·E RojasP Ostrosky-Wegman
Jan 1, 2009·Metallomics : Integrated Biometal Science·Adriana Arita, Max Costa
Apr 2, 2011·PloS One·Kam-Meng Tchou-WongMax Costa
May 26, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Ricardo Martinez-Zamudio, Hyo Chol Ha
Dec 6, 2005·Environmental and Molecular Mutagenesis·Cheng Z DengThomas Albrecht
Nov 28, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Young-Ok Son

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