Use of the ultrasound-based total malignancy score in the management of thyroid nodules

Ultrasonography
Giovanni Guido PompiliGianpaolo Carrafiello

Abstract

The purpose of this study was to validate the role of the total malignancy score (TMS) in identifying thyroid nodules suspicious for malignancy through the sum of their ultrasound features. The local ethical committee approved this prospective observational study. We examined 231 nodules in 231 consecutive patients (164 females and 67 males; age range, 20 to 87 years; median age, 59 years; interquartile range, 48 to 70 years) who underwent ultrasound followed by fine-needle aspiration cytology (FNAC). The nodules were further classified using the TMS, which considers ultrasound features (number, echogenicity, structure, halo, margins, Doppler signal, calcifications, and growth), and the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), which considers cytological features. Patients with non-negative nodules (TBSRTC categories III to VI) underwent histological analysis, repeated FNAC, or 2 years of regular ultrasound follow-up. The associations between the final diagnosis, each of the ultrasound features, and the TMS were estimated using the chi-square test, the Mann-Whitney U test, and multivariate logistic regression. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic accuracy of th...Continue Reading

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Citations

Mar 22, 2019·Ultrasonography·Juan Sebastian Gomez, Luis Fernando Serrano
Aug 20, 2020·Ultrasonography·Leehi Joo, Jung Hwan Baek
Nov 2, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Fan ZhangTooraj Zahedi

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Methods Mentioned

BETA
biopsy

Software Mentioned

Thyroid Imaging Reporting and Data System ( TI - RADS )
SPSS

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