PMID: 9160489Apr 30, 1997Paper

Use of the Wei-Lin-Weissfeld method for the analysis of a recurring and a terminating event

Statistics in Medicine
Q H Li, S W Lagakos

Abstract

We consider application of the Wei-Lin-Weissfeld (WLW) method for multiple failure time data when analysing a disease process consisting of a recurring outcome, such as clinical progression, and a terminating outcome, such as death. In order to adapt WLW for this situation, 'events' must be specified that define multiple failure times and whether these are censored. Various choices of events are possible, and each corresponds to inferences about a different aspect of the underlying disease process. Definitions which regard the terminating outcome as a censor of the recurring outcome focus on specific cause-specific hazard functions, while event definitions which make no distinction between a recurring and terminating outcome focus on hazard functions of the induced failure times. Some event definitions require strong statistical assumptions to yield valid inferences and are not recommended. The application of WLW for recurring/terminating processes is illustrated with the results of two recently conducted clinical trials in persons with HIV.

Citations

Apr 2, 2010·BMC Medical Research Methodology·Jisheng CuiAndrew Tonkin
Feb 14, 2003·The New England Journal of Medicine·Lindon M H WingUNKNOWN Second Australian National Blood Pressure Study Group
Mar 10, 2006·Statistics in Medicine·Masako NishikawaMakiko Ogawa
May 19, 2011·Statistics in Medicine·Liuquan SunShaojun Guo
Jul 25, 2012·Statistics in Medicine·Xuelin Huang, Jing Ning
Feb 13, 2014·Pharmaceutical Statistics·Qi GongLiang Fang
Jul 22, 1998·Statistics in Medicine·C Mahé
Dec 22, 1999·Statistics in Medicine·J T WassellD D Landen
Jun 9, 2009·PLoS Genetics·Guy SellaPeter Andolfatto
Jun 23, 2011·PLoS Computational Biology·Nathan L NehrtMatthew W Hahn
Dec 22, 2006·PloS One·Jeffery P DemuthMatthew W Hahn
Dec 19, 2009·PLoS Computational Biology·João F Matias Rodrigues, Andreas Wagner
Feb 7, 2001·American Journal of Epidemiology·B S KennedyV Vaccarino
Nov 26, 2008·Clinical Trials : Journal of the Society for Clinical Trials·Jisheng CuiAndrew Tonkin
Jun 22, 2016·Circulation·Scott D Solomon, Marc A Pfeffer
Mar 17, 2010·Lifetime Data Analysis·Yanyan LiuHaibo Zhou
Nov 17, 2019·The New England Journal of Medicine·Jean-Claude TardifFrançois Roubille
May 8, 2001·Statistical Methods in Medical Research·J M Albert, H Yun
Jul 8, 2016·Statistics in Medicine·Sijin WenPeter Pisters
Sep 2, 2004·Biometrics·Lei LiuXuelin Huang
Nov 17, 2019·Lifetime Data Analysis·Dongdong LiJohn J Spinelli
May 8, 2001·Statistical Methods in Medical Research·N G Becker, I C Marschner
Jul 6, 2000·Biometrics·D Ghosh, D Y Lin
Nov 6, 2020·Circulation·Benjamin E PetersonUNKNOWN REDUCE-IT Investigators
Nov 1, 2020·European Journal of Clinical Investigation·Michiel DelesieHein Heidbuchel
Jul 14, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lorien S DalrympleGeorge A Kaysen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.