Use of the zebrafish (Danio rerio) to define hematopoiesis
Abstract
Hematopoiesis in the vertebrate is characterized by the induction of ventral mesoderm to form hematopoietic stem cells and the eventual differentiation of these progenitors to form the peripheral blood lineages. Several genes have been implicated in the differentiation and development of hematopoietic and vascular progenitor cells, yet our understanding of the discrete steps involved in the induction of these cells from the ventral mesoderm is still incomplete. One method of delineating these processes is based on the use of lower vertebrates. The zebrafish (Danio rerio) is an especially robust vertebrate system for both isolating and characterizing genes involved in these processes. Hematopoietic mutants have been generated with defects in many of the steps of both the primitive and definitive hematopoietic programs. Cloning of the genes that underlie these mutations should yield valuable details of hematopoiesis and may have therapeutic implications for bone marrow transplantation and stem cell gene therapy.
References
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate
The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages
TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
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