Use of thyroid hormones in relation to pregnancy: a Danish nationwide cohort study

Acta Obstetricia Et Gynecologica Scandinavica
Karin GidénE Jimenez-Solem

Abstract

To determine the rate of exposure of pregnant women to levothyroxine and to assess changes in these rates before, during and after pregnancy. Register-based cohort study. Danish nationwide registers. All women having a live birth in Denmark between 1 January 1997 and 31 December 2010 (n = 912 342). All pregnant women in the study period were identified from the Danish Medical Birth Register. Exposed women were identified from the Danish National Prescription Register, based on redemption of levothyroxine prescriptions before, during or after pregnancy. The rate of pregnant women redeeming levothyroxine prescriptions and maternal characteristics. We identified a fourfold increase in levothyroxine prescription redemption during the study period, from 0.34% in 1997 to 1.39% by 2010. A mean of 0.79% of our cohort received levothyroxine. Most of the women who were using levothyroxine before pregnancy continued the therapy during their pregnancy, but 9.4% stopped redeeming their prescriptions. Overall, 0.28% of our cohort received a levothyroxine prescription for the first time within 9 months after pregnancy. Fewer women than expected received levothyroxine treatment during pregnancy even though a fourfold increase was observed duri...Continue Reading

References

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