Use of time-kill methodology to assess antimicrobial combinations against metronidazole-susceptible and metronidazole-resistant strains of Helicobacter pylori.

Antimicrobial Agents and Chemotherapy
P E Coudron, C W Stratton

Abstract

Optimal therapy for Helicobacter pylori infection to date, consists of metronidazole, bismuth, and tetracycline. This combination, however, is less effective against metronidazole-resistant organisms. We used a time-kill kinetic methodology to assess the bactericidal effects of selected agents, alone and in combination, to a metronidazole-susceptible and a metronidazole-resistant strain of H. pylori. single, double, and triple agents showed increasing bactericidal activity. The combination of metronidazole, bismuth, and tetracycline showed maximal killing effect (no detectable regrowth) against the susceptible strain, but against the resistant strain this combination showed less killing. The time-kill methodology may therefore offer an in vitro approach to the initial selection of agents to be evaluated for the treatment of H. pylori infections.

References

Sep 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M J Blaser
Apr 1, 1995·Journal of Clinical Microbiology·P E Coudron, C W Stratton
Jan 19, 1995·The New England Journal of Medicine·J J SungA K Li
Jul 1, 1993·Antimicrobial Agents and Chemotherapy·M P CooremanK J Hengels
May 1, 1993·Antimicrobial Agents and Chemotherapy·M J PavicićJ De Graaff

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Citations

Dec 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T AlarcónM López-Brea
Mar 28, 2007·Antimicrobial Agents and Chemotherapy·Stefanie HellerStuart Shapiro
Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Margareta SvenssonMikael Sörberg
May 1, 1999·Antimicrobial Agents and Chemotherapy·J K AkadaT Nakazawa
Oct 23, 1997·Clinical Microbiology Reviews·B E DunnM J Blaser

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