Use of tissue-fluid correlations to estimate gentamicin residues in kidney tissue of Holstein steers

Journal of Veterinary Pharmacology and Therapeutics
O A ChiesaM H Thomas

Abstract

Gentamicin continues to be one of the most effective antibiotics for the treatment of gram-negative infections. Greater than 90% of the drug is rapidly eliminated from the body in <2 days, however, a small residue remains bound to the kidney cortex tissue for many months. In beef steers, the gentamicin residue is unacceptable and its presence is monitored by the FAST (Fast Antimicrobial Screen Test) applied to the kidney at the time of slaughter. The sensitivity of the FAST to gentamicin in the kidney cortex is reported to be 100 ng/g, therefore, this level of gentamicin defines the acceptable limit of gentamicin drug residue in the bovine kidney. In the present study, three doses of 4 mg/kg gentamicin was administered intramuscularly to eight steers. Gentamicin was allowed to deplete from the kidneys for a range of times from 7 to 10 months. At slaughter the level of gentamicin in the kidney cortex varied from 91 to 193 ng/g, but a total of 160 FAST tests performed on the kidneys were negative. Blood and urine samples were collected at varying times following the last dose of gentamicin. Kidney tissue samples were collected by laparoscopic surgery in the live steers as well as the final sample obtained at slaughter. Plasma lev...Continue Reading

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Citations

Jun 19, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·F YangZ L Zeng
Dec 17, 2008·Research in Veterinary Science·Oscar Alberto ChiesaMichael Thomas
Sep 29, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Lingli HuangZonghui Yuan
Dec 22, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Xudong ZhuZonghui Yuan
Sep 23, 2016·Journal of Veterinary Pharmacology and Therapeutics·O A ChiesaM J Myers
Aug 13, 2011·Journal of Veterinary Pharmacology and Therapeutics·O A ChiesaJ Von Bredow
Apr 4, 2009·Journal of Chromatography. a·T F H Bovee, M G Pikkemaat

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