Abstract
Gentamicin continues to be one of the most effective antibiotics for the treatment of gram-negative infections. Greater than 90% of the drug is rapidly eliminated from the body in <2 days, however, a small residue remains bound to the kidney cortex tissue for many months. In beef steers, the gentamicin residue is unacceptable and its presence is monitored by the FAST (Fast Antimicrobial Screen Test) applied to the kidney at the time of slaughter. The sensitivity of the FAST to gentamicin in the kidney cortex is reported to be 100 ng/g, therefore, this level of gentamicin defines the acceptable limit of gentamicin drug residue in the bovine kidney. In the present study, three doses of 4 mg/kg gentamicin was administered intramuscularly to eight steers. Gentamicin was allowed to deplete from the kidneys for a range of times from 7 to 10 months. At slaughter the level of gentamicin in the kidney cortex varied from 91 to 193 ng/g, but a total of 160 FAST tests performed on the kidneys were negative. Blood and urine samples were collected at varying times following the last dose of gentamicin. Kidney tissue samples were collected by laparoscopic surgery in the live steers as well as the final sample obtained at slaughter. Plasma lev...Continue Reading
References
Mar 1, 1977·Journal of Toxicology and Environmental Health·H D MercerR A Sams
Dec 1, 1976·Kidney International·J FabreC Regamey
Mar 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·S A Brown, J E Riviere
Mar 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·G E BurrowsB Martin
Sep 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·S A BrownL P Dix
Apr 1, 1985·Nihon juigaku zasshi. The Japanese journal of veterinary science·Y TakahashiE Kokue
Oct 1, 1985·Nihon juigaku zasshi. The Japanese journal of veterinary science·Y TakahashiE Kokue
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·G R AronoffF C Luft
Jun 1, 1983·Journal of Veterinary Pharmacology and Therapeutics·S A Al-GuedawyB K Gustafsson
Jun 11, 1999·Journal of Colloid and Interface Science·V A Nierstrasz, G Frens
Jul 17, 1999·Trends in Plant Science· Hans de Jong JP Zabel
Oct 24, 2000·Journal of Analytical Toxicology·M A HuestisK L Preston
Dec 8, 2000·Journal of Veterinary Pharmacology and Therapeutics·R D Fisch
Mar 31, 2001·Journal of the American Veterinary Medical Association·UNKNOWN AVMA Panel on Euthanasia. American Veterinary Medical Association
Dec 1, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·Catherine A Hammett-StablerDonald J Cannon
Apr 9, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Abdulsalam I Al-AmoudHenry Chrystyn
Jul 5, 2003·Current Biology : CB·Hollis Cline
Nov 20, 2003·Trends in Neurosciences·Hollis Cline
May 21, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·David N HellerKeesla Moulton
Citations
Jun 19, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·F YangZ L Zeng
Dec 17, 2008·Research in Veterinary Science·Oscar Alberto ChiesaMichael Thomas
Feb 18, 2016·Journal of Agricultural and Food Chemistry·Lingli HuangZonghui Yuan
Sep 29, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Lingli HuangZonghui Yuan
Jun 17, 2009·Journal of Dairy Science·A A CattaneoJ T LeJeune
Dec 22, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Xudong ZhuZonghui Yuan
Sep 23, 2016·Journal of Veterinary Pharmacology and Therapeutics·O A ChiesaM J Myers
Aug 13, 2011·Journal of Veterinary Pharmacology and Therapeutics·O A ChiesaJ Von Bredow
May 2, 2013·Journal of Veterinary Pharmacology and Therapeutics·B YangZ H Yuang
Aug 25, 2020·Journal of Veterinary Internal Medicine·Joe S SmithAmanda J Kreuder
May 7, 2010·Journal of Agricultural and Food Chemistry·Yu LiuZonghui Yuan
Apr 4, 2009·Journal of Chromatography. a·T F H Bovee, M G Pikkemaat